We combine diffuse optical tomography for detecting and localizing an inhomogeneity in a two-layered tissue and diffuse optical spectroscopy (DOS) for characterizing the spectrum of that inhomogeneity. For detecting and localizing an inhomogeneity, we reduce the number of unknowns substantially by seeking only the location and size of the inhomogeneity. Then, we seek to recover an unknown specific tumor component of that inhomogeneity from spectral data. In doing so, we develop a method for distinguishing between healthy and tumorous lesions. We demonstrate the utility of this theory with numerical simulations.
© 2012 Optical Society of America
Original Manuscript: October 17, 2011
Revised Manuscript: January 9, 2012
Manuscript Accepted: January 10, 2012
Published: March 15, 2012
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics
Pedro González-Rodríguez, Diego Álvarez, Arnold D. Kim, and Miguel Moscoso, "Combining diffuse optical tomography and spectroscopy to detect and characterize lesions in two-layered tissues," J. Opt. Soc. Am. A 29, 450-456 (2012)