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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 4 — May. 22, 2013

Analytical solutions for diffuse fluorescence spectroscopy/imaging in biological tissues. Part II: comparison and validation

Kalyan Ram Ayyalasomayajula and Phaneendra K. Yalavarthy  »View Author Affiliations


JOSA A, Vol. 30, Issue 3, pp. 553-559 (2013)
http://dx.doi.org/10.1364/JOSAA.30.000553


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Abstract

The analytical solutions for the coupled diffusion equations that are encountered in diffuse fluorescence spectroscopy/imaging for regular geometries were compared with the well-established numerical models, which are based on the finite element method. Comparison among the analytical solutions obtained using zero boundary conditions and extrapolated boundary conditions (EBCs) was also performed. The results reveal that the analytical solutions are in close agreement with the numerical solutions, and solutions obtained using EBCs are more accurate in obtaining the mean time of flight data compared to their counterpart. The analytical solutions were also shown to be capable of providing bulk optical properties through a numerical experiment using a realistic breast model.

© 2013 Optical Society of America

OCIS Codes
(000.3860) General : Mathematical methods in physics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(300.2530) Spectroscopy : Fluorescence, laser-induced

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 11, 2012
Manuscript Accepted: January 13, 2013
Published: February 28, 2013

Virtual Issues
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Kalyan Ram Ayyalasomayajula and Phaneendra K. Yalavarthy, "Analytical solutions for diffuse fluorescence spectroscopy/imaging in biological tissues. Part II: comparison and validation," J. Opt. Soc. Am. A 30, 553-559 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-30-3-553


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References

  1. K. R. Ayyalasomayajula and P. K. Yalavarthy, “Analytical solutions for diffuse fluorescence spectroscopy/imaging of biological tissues in regular geometries. Part I: zero and extrapolated boundary conditions,” J. Opt. Soc. Am. A30, 537–552(2013).
  2. H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithms for numerical model and image reconstruction algorithms,” Commun. Numer. Methods Eng. 25, 711–732 (2009). [CrossRef]
  3. M. S. Patterson, B. Chance, and B. C. Wilson, “Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties,” Appl. Opt. 28, 2331–2336 (1989). [CrossRef]
  4. M. Sadoqi, P. Riseborough, and S. Kumar, “Analytical models for time resolved fluorescence spectroscopy in tissues,” Phys. Med. Biol. 46, 2725–2743 (2001). [CrossRef]
  5. S. L. Jacques and B. W. Pogue, “Tutorial on diffuse light transport,” J. Biomed. Opt. 13, 041302 (2008). [CrossRef]
  6. H. S. Carslaw and J. C. Jaeger, Conduction of Heat in Solids, 2nd ed. (Oxford Science, 1946).
  7. C. K. Hayakawa, J. Spanier, F. Bevilacqua, A. K. Dunn, J. S. You, B. J. Tromberg, and V. Venugopalan, “Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues” Opt. Lett. 26, 1335–1337 (2001). [CrossRef]
  8. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, “A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the breast in vivo,” Rev. Sci. Instrum. 72, 1817–1824 (2001). [CrossRef]
  9. E. M. Sevick-Muraca and J. C. Rasmussen, “Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine,” J. Biomed. Opt. 13, 041303 (2008). [CrossRef]
  10. S. Patwardhan, S. Bloch, S. Achilefu, and J. Culver, “Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice,” Opt. Express 13, 2564–2577 (2005). [CrossRef]

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