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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 4 — May. 22, 2013

Analytical solutions for diffuse fluorescence spectroscopy/imaging in biological tissues. Part II: comparison and validation

Kalyan Ram Ayyalasomayajula and Phaneendra K. Yalavarthy  »View Author Affiliations

JOSA A, Vol. 30, Issue 3, pp. 553-559 (2013)

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The analytical solutions for the coupled diffusion equations that are encountered in diffuse fluorescence spectroscopy/imaging for regular geometries were compared with the well-established numerical models, which are based on the finite element method. Comparison among the analytical solutions obtained using zero boundary conditions and extrapolated boundary conditions (EBCs) was also performed. The results reveal that the analytical solutions are in close agreement with the numerical solutions, and solutions obtained using EBCs are more accurate in obtaining the mean time of flight data compared to their counterpart. The analytical solutions were also shown to be capable of providing bulk optical properties through a numerical experiment using a realistic breast model.

© 2013 Optical Society of America

OCIS Codes
(000.3860) General : Mathematical methods in physics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(300.2530) Spectroscopy : Fluorescence, laser-induced

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 11, 2012
Manuscript Accepted: January 13, 2013
Published: February 28, 2013

Virtual Issues
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics

Kalyan Ram Ayyalasomayajula and Phaneendra K. Yalavarthy, "Analytical solutions for diffuse fluorescence spectroscopy/imaging in biological tissues. Part II: comparison and validation," J. Opt. Soc. Am. A 30, 553-559 (2013)

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