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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 5 — Apr. 29, 2014

Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope

Yusufu N. Sulai, Drew Scoles, Zachary Harvey, and Alfredo Dubra  »View Author Affiliations


JOSA A, Vol. 31, Issue 3, pp. 569-579 (2014)
http://dx.doi.org/10.1364/JOSAA.31.000569


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Abstract

Imaging of the retinal vascular structure and perfusion was explored by confocal illumination and nonconfocal detection in an adaptive optics scanning light ophthalmoscope (AOSLO), as an extension of the work by Chui et al. [Biomed. Opt. Express 3, 2537 (2012)]. Five different detection schemes were evaluated at multiple retinal locations: circular mask, annular mask, circular mask with filament, knife-edge, and split-detector. Given the superior image contrast in the reflectance and perfusion maps, the split-detection method was further tested using pupil apodization, polarized detection, and four different wavelengths. None of these variations provided noticeable contrast improvement. The noninvasive visualization of capillary flow and structure provided by AOSLO split-detection shows great promise for studying ocular and systemic conditions that affect the retinal vasculature.

© 2014 Optical Society of America

OCIS Codes
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology
(290.4210) Scattering : Multiple scattering
(110.1080) Imaging systems : Active or adaptive optics

ToC Category:
Vision, Color, and Visual Optics

History
Original Manuscript: November 15, 2013
Revised Manuscript: January 2, 2014
Manuscript Accepted: January 3, 2014
Published: February 14, 2014

Virtual Issues
Vol. 9, Iss. 5 Virtual Journal for Biomedical Optics
March 21, 2014 Spotlight on Optics

Citation
Yusufu N. Sulai, Drew Scoles, Zachary Harvey, and Alfredo Dubra, "Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope," J. Opt. Soc. Am. A 31, 569-579 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-31-3-569


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