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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 9 — Sep. 8, 2008

Optical resonances in microcylinders: response to perturbations for biosensing

L. Chantada, N. I. Nikolaev, A. L. Ivanov, P. Borri, and W. Langbein  »View Author Affiliations


JOSA B, Vol. 25, Issue 8, pp. 1312-1321 (2008)
http://dx.doi.org/10.1364/JOSAB.25.001312


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Abstract

Whispering gallery modes (WGMs) in dielectric microcylinders are investigated numerically as sensitive probes of the surrounding medium, for applications in chemical sensing and biosensing. We consider a geometry where WGMs are exited via frustrated total internal reflection from a planar dielectric substrate, as reported in recent experiments. The optical coupling between the substrate and the cylinder yields a WGM broadening exponentially decreasing with increasing distance between the cylinder and the substrate. We also consider a separation layer between the substrate and the cylinder that results in a WGM broadening and shift depending on the index mismatch between the layer and the surrounding medium, and find that Q values > 10 5 are possible for a mismatch in the few percent range. For biosensing applications we calculate the effect of single and multiple cylinder-shaped particles of different sizes attached to the cylinder surface to simulate biological analytes. We find not only WGM shifts but also broadenings and splittings acting as sensitive indicators of different properties of the analytes. In particular, in the case of a single particle, both particle size and refractive index can be determined from the WGM shift and broadening, opening the perspective to a new modality of biosensing applicable to single objects such as viruses or bacteria. In the multiparticle case, the results are statistically analyzed in terms of their surface coverage.

© 2008 Optical Society of America

OCIS Codes
(260.5740) Physical optics : Resonance
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(140.3948) Lasers and laser optics : Microcavity devices
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Remote Sensing and Sensors

History
Original Manuscript: April 8, 2008
Revised Manuscript: May 22, 2008
Manuscript Accepted: May 26, 2008
Published: July 24, 2008

Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics

Citation
L. Chantada, N. I. Nikolaev, A. L. Ivanov, P. Borri, and W. Langbein, "Optical resonances in microcylinders: response to perturbations for biosensing," J. Opt. Soc. Am. B 25, 1312-1321 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josab-25-8-1312


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References

  1. N. Noto, F. Vollmer, D. Keng, I. Teraoka, and S. Arnold, “Nanolayer characterization through wavelength multiplexing of a microsphere resonator,” Opt. Lett. 30, 510-512 (2005). [CrossRef] [PubMed]
  2. F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, “Protein detection by optical shift of a resonant microcavity,” Appl. Phys. Lett. 80, 4057-4059 (2002). [CrossRef]
  3. F. Vollmer, S. Arnold, D. Braun, I. Teraoka, and A. Libshaber, “Multiplexed DNA quantification by spectroscopic shift of two microsphere cavities,” Biophys. J. 85, 1974-1979 (2003). [CrossRef] [PubMed]
  4. M. Hosodaa and T. Shigaki, “Degeneracy breaking of optical resonance modes in rolled-up spiral microtubes,” Appl. Phys. Lett. 90, 181107 (2007). [CrossRef]
  5. T. Ling and L. J. Guo, “A unique resonance mode observed in a prismcoupled microtube resonator sensor with superior index sensitivity,” Opt. Express 15, 17424-17432 (2007). [CrossRef] [PubMed]
  6. M. Sumetsky, R. S. Windeler, Y. Dulashko, and X. Fan, “Optical liquid ring resonator sensor,” Opt. Express 15, 14376-14381 (2007). [CrossRef] [PubMed]
  7. A. M. Armani, R. P. Kulkarni, S. E. Fraser, R. C. Flagan, and K. J. Vahala, “Label-free, single-molecule detection with optical microcavities,” Science 317, 783-787 (2007). [CrossRef] [PubMed]
  8. H.-C. Ren, F. Vollmer, S. Arnold, and A. Libchaber, “High-Q microsphere biosensor-analysis for adsorption of rodlike bacteria,” Opt. Express 15, 17410-17422 (2007). [CrossRef] [PubMed]
  9. C.-M. Yuan, “Efficient light scattering modeling for alignment, metrology, and resist exposure in photolithography,” IEEE Trans. Electron Devices 39, 1588-1598 (1992). [CrossRef]
  10. N. I. Nikolaev and A. Erdmann, “Rigorous simulation of alignment for microlithography,” J. Microlithogr., Microfabr., Microsyst. 2, 220-226 (2003). [CrossRef]
  11. M. G. Moharam, D. A. Pommet, and E. B. Grann, “Stable implementation of the rigorous coupled-wave analysis for surface-relief gratings: enhanced transmittance matrix approach,” J. Opt. Soc. Am. A 12, 1077-1086 (1995). [CrossRef]
  12. J. A. Stratton, Electro Magnetic Theory (McGraw-Hill, 1941).
  13. D. Meschede, Optics, Light and Lasers (Wiley VCH, 2003).
  14. This assumes that the divergence of the Gaussian beam θdiv=λ/(πw0nb) is much less than π/2−θ.
  15. M. L. Gorodetsky and V. S. Ilchenko, “Optical microsphere resonators: optimal coupling to high-q whispering-gallery modes,” J. Opt. Soc. Am. B 16, 147-154 (1999). [CrossRef]
  16. The coupling to the substrate also breaks the rotational symmetry, but we have verified that in the simulations the mode splitting is dominated by the numerical discretization.
  17. S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer, “Shift of whispering-gallery modes in microspheres by protein adsorption,” Opt. Lett. 28, 272-274 (2003). [CrossRef] [PubMed]
  18. I. Teraoka, S. Arnold, and F. Vollmer, “Perturbation approach to resonance shifts of whispering-gallery modes in a dielectric microsphere as a probe of a surrounding medium,” J. Opt. Soc. Am. B 20, 1937-1946 (2003). [CrossRef]
  19. M. Cai, O. Painter, and K. J. Vahala, “Observation of critical coupling in a fiber taper to a silica-microsphere whispering-gallery mode system,” Phys. Rev. Lett. 85, 74-77 (2000). [CrossRef] [PubMed]
  20. J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical,” Appl. Phys. Lett. 91, 141116 (2007). [CrossRef]
  21. H. J. Coles, B. R. Jennings, and V. J. Morris, “Refractive index increment measurement of bacterial suspensions,” Phys. Med. Biol. 20, 310-313 (1975). [CrossRef] [PubMed]
  22. K. R. Hiremath and V. N. Astratov, “Perturbations of whispering gallery modes by nanoparticles embedded in microcavities,” Opt. Express 16, 5421-5426 (2008). [CrossRef] [PubMed]

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