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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 6 — Jun. 13, 2006

Characteristics of a paired surface plasma waves biosensor

Chien Chou, Hsieh-Ting Wu, Yen-Chen Huang, Yi-Ling Chen, and Wen-Chuan Kuo  »View Author Affiliations

Optics Express, Vol. 14, Issue 10, pp. 4307-4315 (2006)

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A novel paired surface plasma wave biosensor (PSPWB) is described and setup. By integrating the features of a common-path optical heterodyne interferometer and the amplitude-ratio detection mode, the PSPWB not only produces a high detection sensitivity but also provides a large dynamic measurement range for effective refractive index ( Δneff ) based on amplitude-sensitive detection method. Thus, the performance of PSPWB becomes equivalent to shot-noise limited of a conventional SPR biosensor. To our knowledge, this novel PSPWB shows the highest detection sensitivity on Δneff when compared with conventional SPR biosensors using either a non-interferometric or interferometric technique. The experimental results correctly verify the properties of a PSPWB that the detection sensitivity is an order of 10-7 refractive index unit (RIU) when measuring a 0.001% sucrose-water solution. This result confirms the detection sensitivity up to 10-9 RIU of the IgG/anti-IgG interaction in real time successfully. Furthermore, a dynamic range of 105 using PSPWB was also obtained.

© 2006 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology

ToC Category:
Instrumentation, Measurement, and Metrology

Original Manuscript: March 27, 2006
Revised Manuscript: May 9, 2006
Manuscript Accepted: May 9, 2006
Published: May 15, 2006

Virtual Issues
Vol. 1, Iss. 6 Virtual Journal for Biomedical Optics

Chien Chou, Hsieh-Ting Wu, Yen-Chen Huang, Wen-Chuan Kuo, and Yi-Ling Chen, "Characteristics of a paired surface plasma waves biosensor," Opt. Express 14, 4307-4315 (2006)

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