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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 6 — Jun. 13, 2006

In vivo optical frequency domain imaging of human retina and choroid

Edward C. W. Lee, Johannes F. de Boer, Mircea Mujat, Hyungsik Lim, and Seok H. Yun  »View Author Affiliations


Optics Express, Vol. 14, Issue 10, pp. 4403-4411 (2006)
http://dx.doi.org/10.1364/OE.14.004403


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Abstract

Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a highperformance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz, sensitivity of >92 dB over a depth range of 2.4 mm with an optical exposure level of 550 µW, and deep penetration into the choroid. Using these new technologies, we demonstrate comprehensive human retina, optic disc, and choroid imaging in vivo. This advance enables us to view choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroidal as well as retinal diseases.

© 2006 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(140.3600) Lasers and laser optics : Lasers, tunable
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 7, 2006
Revised Manuscript: April 25, 2006
Manuscript Accepted: April 27, 2006
Published: May 15, 2006

Virtual Issues
Vol. 1, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Edward C. Lee, Johannes F. de Boer, Mircea Mujat, Hyungsik Lim, and Seok H. Yun, "In vivo optical frequency domain imaging of human retina and choroid," Opt. Express 14, 4403-4411 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-14-10-4403


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