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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 7 — Jul. 17, 2006

Clutter rejection filters for optical Doppler tomography

Hongwu Ren and Xingde Li  »View Author Affiliations


Optics Express, Vol. 14, Issue 13, pp. 6103-6112 (2006)
http://dx.doi.org/10.1364/OE.14.006103


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Abstract

The phase-resolved (PR) method is widely used in optical Doppler tomography (ODT) to estimate flow velocity from sequential axial line (A-line) signals. However, the A-line signal contains clutter components induced by stationary or relative slow moving clutter scatterers such as the blood vessel wall or the overall sample with motion artifacts. The clutter component affects the accuracy in quantifying Doppler flow. In this paper, we present a delay line filter (DLF) to reject the clutter effect and enables moving-scatterer-sensitive ODT (MSS-ODT) imaging of flow. The frequency response of DLFs of different orders is theoretically analyzed and we find that a first-order phase-shifted DLF is effective for clutter rejection and for improving the sensitivity to moving scatterers such as moving blood cells. The proposed MSS-ODT method has been experimentally applied to Doppler flow imaging in a capillary flow phantom and a mouse ear in vivo. The ODT data were acquired using a real-time spectral-domain optical coherence tomography (SD-OCT) system with an A-line acquisition rate of 12.3k/s. Doppler flow images obtained with MSS-ODT and the conventional PR-ODT techniques are compared and MSS-ODT is found to be more sensitive to Doppler flow and more accurate in determining vessel size. Small blood vessels that might be masked by clutter signals in PROCT are successfully recovered by MSS-ODT.

© 2006 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 20, 2006
Revised Manuscript: June 19, 2006
Manuscript Accepted: June 20, 2006
Published: June 26, 2006

Virtual Issues
Vol. 1, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Hongwu Ren and Xingde Li, "Clutter rejection filters for optical Doppler tomography," Opt. Express 14, 6103-6112 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-14-13-6103


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