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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 4 — Apr. 12, 2006

Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media

C. D’Andrea, L. Spinelli, A. Bassi, A. Giusto, D. Contini, J. Swartling, A. Torricelli, and R. Cubeddu  »View Author Affiliations

Optics Express, Vol. 14, Issue 5, pp. 1888-1898 (2006)

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We have devised and experimentally validated, on tissue-simulating phantoms and in vivo, a time-resolved spectral fitting analysis for direct assessment of chromophore concentrations and scattering parameters. Experimental data have been acquired with a time-resolved broadband system based on supercontinuum light generated in a photonic crystal fiber and a 32 channel Time Correlated Single Photon Counting system. The novel method is more robust than conventional techniques, especially at low signal-to-noise ratio.

© 2006 Optical Society of America

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 3, 2006
Revised Manuscript: February 24, 2006
Manuscript Accepted: February 26, 2006
Published: March 6, 2006

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

C. D'Andrea, L. Spinelli, A. Bassi, A. Giusto, D. Contini, J. Swartling, A. Torricelli, and R. Cubeddu, "Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media," Opt. Express 14, 1888-1898 (2006)

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