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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 4 — Apr. 12, 2006

Multimodal near infrared spectral imaging as an exploratory tool for dysplastic esophageal lesion identification

Chad A. Lieber, Shiro Urayama, Nazir Rahim, Raymond Tu, Ramez Saroufeem, Boris Reubner, and Stavros G. Demos  »View Author Affiliations

Optics Express, Vol. 14, Issue 6, pp. 2211-2219 (2006)

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We explore nine different combinations of fluorescence, light scattering, and polarization spectral imaging approaches in the near-infrared spectral region toward the diagnosis of pathologic and normal esophageal lesions. The combinations of all the imaging techniques were evaluated for maximal sensitivity and specificity. The results suggest that this multimodal approach is capable of highly accurate detection of the presence of pathologic tissue.

© 2006 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 22, 2005
Revised Manuscript: March 6, 2006
Manuscript Accepted: March 8, 2006
Published: March 20, 2006

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Chad A. Lieber, Shiro Urayama, Nazir Rahim, Raymond Tu, Ramez Saroufeem, Boris Reubner, and Stavros G. Demos, "Multimodal near infrared spectral imaging as an exploratory tool for dysplastic esophageal lesion identification," Opt. Express 14, 2211-2219 (2006)

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  1. American Cancer Society. Cancer Facts and Figures 2005, Atlanta: American Cancer Society (2005).
  2. M. Panjehpour, B. Overholt, T. Vo-Dinh, R. Haggitt, D. Edwards, and F. Buckley, "Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus," Gastroenterology 111, 93-101 (1996). [CrossRef] [PubMed]
  3. H. Tajiri, M. Kobayashi, K. Izuishi, and S. Yoshida, "Fluorescence endoscopy in the gastrointestinal tract," Dig. Endosc. 12, S28-S31 (2000). [CrossRef]
  4. I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M. G. Muller, Q. Zhang, K. Badizadegan, D. Sun, G. A. Thomas, L. T. Perelman, and M. S. Feld, "Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus," Gastroenterology 120, 1620-1629 (2001). [CrossRef] [PubMed]
  5. M. G. Shim, L. M. Song, N. E. Marcon, and B. C. Wilson, "In vivo near-infrared Raman spectroscopy: demonstration of feasibility during clinical gastrointestinal endoscopy," Photochem. Photobiol. 72, 146-150 (2000). [PubMed]
  6. C. Kendall, N. Stone, N. Shepherd, K. Geboes, B. Warren, R. Bennett, and H. Barr, "Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus," J. Pathol. 200, 602-609 (2003). [CrossRef] [PubMed]
  7. M. B. Wallace, L. T. Perelman, V. Backman, J. M. Crawford, M. Fitzmaurice, M. Seiler, K. Badizadegan, S. J. Shields, I. Itzkan, R. R. Dasari, J. Van Dam, and M. S. Feld, "Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy," Gastroenterology 119, 677-682 (2000). [CrossRef] [PubMed]
  8. D. C. Pickard, I. J. Bigio, S. G. Bown, L. B. Lovat, P. M. Ripley, M. Novelli, "Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus," in Optical Biopsy IV, R. R. Alfono ed., Proc. SPIE 4613, 234-243, (2002). [CrossRef]
  9. J. S. Wang, J. S. Shi, Y. Z. Xu, X. Y Duan, L. Zhang, J. Wang, L. M. Yang, S. F. Weng, and J. G. Wu, "FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus," World J. Gastroenterol. 9, 1897-1899 (2003). [PubMed]
  10. Q. B. Li, X. J. Sun, Y. Z. Xu, L. M. Yang, Y. F. Zhang, S. F. Weng, J. S. Shi, and J. G. Wu, "Diagnosis of gastric inflammation and malignancy in Endoscopic biopsies based on Fourier transform infrared Spectroscopy," Clin. Chem. 51, 346-350 (2005). [CrossRef] [PubMed]
  11. L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, "Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution," Phys. Rev. Lett. 80, 627-630 (1998). [CrossRef]
  12. H. Fang, M. Ollero, E. Vitkin, L. M. Kimerer, P. B. Cipolloni, M. M. Zaman, S. D. Freedman, I. J. Bigio, I. Itzkan, E. B. Hanlon, L. T. Perelman, "Noninvasive sizing of subcellular organelles with light scattering spectroscopy," IEEE J. Sel. Top. Quantum Electron. 9, 267-276 (2003). [CrossRef]
  13. R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, "Imaging human epithelial properties with polarized light-scattering spectroscopy," Nat. Med. 7, 1245-1248 (2001). [CrossRef] [PubMed]
  14. S. G. Demos, R. Gandour-Edwards, R. Ramsamooj, and R. D. White, "Near-infrared autofluorescence imaging for detection of cancer," J. Biomed. Opt. 9, 587-592 (2004). [CrossRef] [PubMed]
  15. S. G. Demos, R. Bold, R. D. White, and R. Ramsamooj, "Investigation of near infrared autofluorescence imaging for the detection of breast cancer," IEEE J. Sel. Top. Quantum Electron. 11, 791-798 (2005). [CrossRef]
  16. M. T. Moesta, B. Ebert, T. Handke, D. Nolte, C. Nowak, W. E. Haensch, R. K. Pandey, T. J. Dougherty, H. Rinneberg, P. M. Schlag, "Protoporphyrin IX occurs naturally in colorectal cancers and their metastases," Cancer Res. 61, 991-999 (2001) [PubMed]

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