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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy: comment

Jimmy Bak and Thomas M. Jørgensen  »View Author Affiliations

Optics Express, Vol. 15, Issue 10, pp. 5997-5999 (2007)

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The authors of the work: ‘Chromosomal analysis and identification based on optical tweezers and raman spectroscopy’ [Opt. Express 14, 5385 (2006], claim that they have been able to identify and differentiate between three human chromosomes with an optical-tweezer - Raman Spectroscopic experimental (LTRS) set-up. The results and conclusions as they are presented in the paper are questionable, however, when the spectral data and data analysis are studied in greater detail.

© 2007 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.5660) Medical optics and biotechnology : Raman spectroscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 7, 2006
Manuscript Accepted: January 23, 2007
Published: May 1, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Jimmy Bak and Thomas M. Jørgensen, "Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy: comment," Opt. Express 15, 5997-5999 (2007)

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  1. J. F. Ojeda, C. Xie, Y-Q. Li, F. E. Bertrand, J. Wiley, and T. J. McConell, "Chromosomal analysis and identification based on optical tweezers and raman spectroscopy," Opt. Express 14, 5385 (2006). [CrossRef] [PubMed]
  2. G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000). [CrossRef]
  3. N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004). [CrossRef] [PubMed]
  4. S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005). [CrossRef]

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