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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method

Lorenzo Spinelli, Fabrizio Martelli, Andrea Farina, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, and Giovanni Zaccanti  »View Author Affiliations

Optics Express, Vol. 15, Issue 11, pp. 6589-6604 (2007)

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In this paper, a general method to calibrate the absorption coefficient of an absorber and the reduced scattering coefficient of a liquid diffusive medium, based on time-resolved measurements, is reported. An exhaustive analysis of the error sources affecting the estimation is also performed. The method has been applied with a state-of-the-art time-resolved instrumentation to determine the intrinsic absorption coefficient of Indian ink and the reduced scattering coefficient of Intralipid-20%, with a standard error smaller than 1% and 2%, respectively. Finally, the results have been compared to those retrieved for the same compounds by applying a continuous wave method recently published, obtaining an agreement within the error bars. This fact represents a cross validation of the two independent calibration methods.

© 2007 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 7, 2007
Revised Manuscript: April 20, 2007
Manuscript Accepted: May 3, 2007
Published: May 14, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Lorenzo Spinelli, Fabrizio Martelli, Andrea Farina, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, and Giovanni Zaccanti, "Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method," Opt. Express 15, 6589-6604 (2007)

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