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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 7 — Jul. 16, 2007

Three-dimensional visualization of choroidal vessels by using standard and ultra-high resolution scattering optical coherence angiography

Youngjoo Hong, Shuichi Makita, Masahiro Yamanari, Masahiro Miura, Soohyun Kim, Toyohiko Yatagai, and Yoshiaki Yasuno  »View Author Affiliations

Optics Express, Vol. 15, Issue 12, pp. 7538-7550 (2007)

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Scattering optical coherence angiography (S-OCA) is a noninvasive imaging method that is based on the high-speed standard 800nm band spectral-domain optical coherence tomography (SD-OCT) and the ultra-high-resolution SD-OCT which has the axial resolution of 6.1 μm and 2.9 μm in tissue, respectively. In this paper, we have demonstrated the use of this method for in vivo human retinal imaging. A three-dimensional view of the choroidal vasculature was obtained by segmenting the choroidal vessels; this was done using intensity threshold based binarization at each depth plane relative to the retinal pigment epithelium. A vascular projection image was obtained by integrating the segmented choroidal vasculature. In order to assess the feasibility of the proposed method, we compared these images with those obtained using existing invasive methods such as fluorescein angiography and indocyanine green angiography. Clinically worthful images are obtained from the application of S-OCA to the age-related macular degeneration and polypoidal choroidal vasculopathy.

© 2007 Optical Society of America

OCIS Codes
(100.6890) Image processing : Three-dimensional image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 22, 2007
Revised Manuscript: May 2, 2007
Manuscript Accepted: May 3, 2007
Published: June 5, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Youngjoo Hong, Shuich Makita, Masahiro Yamanari, Masahiro Miura, Soohyun Kim, Toyohiko Yatagai, and Yoshiaki Yasuno, "Three-dimensional visualization of choroidal vessels by using standard and ultra-high resolution scattering optical coherence angiography," Opt. Express 15, 7538-7550 (2007)

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