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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 7 — Jul. 16, 2007

Silicon-on-Insulator microring resonator for sensitive and label-free biosensing

Katrien De Vos, Irene Bartolozzi, Etienne Schacht, Peter Bienstman, and Roel Baets  »View Author Affiliations


Optics Express, Vol. 15, Issue 12, pp. 7610-7615 (2007)
http://dx.doi.org/10.1364/OE.15.007610


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Abstract

Label-free biosensors attempt to overcome the stability and reliability problems of biosensors relying on the detection of labeled molecules. We propose a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10μm2. The resonance wavelength shift that occurs when the surroundings of a cavity is changed, is used for sensing. While theoretically the performance for bulk refractive index changes is moderate (10-5), this device performs outstanding in terms of absolute molecular mass sensing (theoretical sensitivity of 1fg molecular mass) thanks to its extremely small dimensions. We use the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml. Fabrication with Deep UV lithography allows for cheap mass production and integration with electronic functions for complete lab-on-chip devices.

© 2007 Optical Society of America

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators

ToC Category:
Integrated Optics

History
Original Manuscript: March 27, 2007
Revised Manuscript: May 30, 2007
Manuscript Accepted: May 30, 2007
Published: June 6, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Katrien De Vos, Irene Bartolozzi, Etienne Schacht, Peter Bienstman, and Roel Baets, "Silicon-on-Insulator microring resonator for sensitive and label-free biosensing," Opt. Express 15, 7610-7615 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-12-7610


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