Prediction of the limit of detection of an optical resonant reflection biosensor
Optics Express, Vol. 15, Issue 14, pp. 8972-8978 (2007)
http://dx.doi.org/10.1364/OE.15.008972
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Abstract
A prediction of the limit of detection of an optical resonant reflection biosensor is presented. An optical resonant reflection biosensor using a guided-mode resonance filter is one of the most promising label-free optical immunosensors due to a sharp reflectance peak and a high sensitivity to the changes of optical path length. We have simulated this type of biosensor using rigorous coupled wave theory to calculate the limit of detection of the thickness of the target protein layer. Theoretically, our biosensor has an estimated ability to detect thickness change approximately the size of typical antigen proteins. We have also investigated the effects of the absorption and divergence of the incident light on the detection ability of the biosensor.
© 2007 Optical Society of America
OCIS Codes
(230.1950) Optical devices : Diffraction gratings
(230.7400) Optical devices : Waveguides, slab
ToC Category:
Optical Devices
History
Original Manuscript: May 8, 2007
Revised Manuscript: June 25, 2007
Manuscript Accepted: June 25, 2007
Published: July 5, 2007
Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Jongcheol Hong, Kyung-Hyun Kim, Jae-Heon Shin, Chul Huh, and Gun Yong Sung, "Prediction of the limit of detection of an optical resonant reflection biosensor," Opt. Express 15, 8972-8978 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-14-8972
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