OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 8 — Aug. 10, 2007

Prediction of the limit of detection of an optical resonant reflection biosensor

Jongcheol Hong, Kyung-Hyun Kim, Jae-Heon Shin, Chul Huh, and Gun Yong Sung  »View Author Affiliations


Optics Express, Vol. 15, Issue 14, pp. 8972-8978 (2007)
http://dx.doi.org/10.1364/OE.15.008972


View Full Text Article

Enhanced HTML    Acrobat PDF (114 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A prediction of the limit of detection of an optical resonant reflection biosensor is presented. An optical resonant reflection biosensor using a guided-mode resonance filter is one of the most promising label-free optical immunosensors due to a sharp reflectance peak and a high sensitivity to the changes of optical path length. We have simulated this type of biosensor using rigorous coupled wave theory to calculate the limit of detection of the thickness of the target protein layer. Theoretically, our biosensor has an estimated ability to detect thickness change approximately the size of typical antigen proteins. We have also investigated the effects of the absorption and divergence of the incident light on the detection ability of the biosensor.

© 2007 Optical Society of America

OCIS Codes
(230.1950) Optical devices : Diffraction gratings
(230.7400) Optical devices : Waveguides, slab

ToC Category:
Optical Devices

History
Original Manuscript: May 8, 2007
Revised Manuscript: June 25, 2007
Manuscript Accepted: June 25, 2007
Published: July 5, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Jongcheol Hong, Kyung-Hyun Kim, Jae-Heon Shin, Chul Huh, and Gun Yong Sung, "Prediction of the limit of detection of an optical resonant reflection biosensor," Opt. Express 15, 8972-8978 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-14-8972


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. Schlensog, T. Gronewold, M. Tewesa, M. Famulok, and E. Quandt, "A love-wave biosensor using nucleic acids as ligands," Sens. Actuators B 101, 308-315 (2004). [CrossRef]
  2. R. Schasfoort, R. Kooyman, P. Bergveld, and J. Greve, "A new approach to immunoFET operation," Biosens. Bioelectron. 5, 103-124 (1990). [CrossRef] [PubMed]
  3. J. Saarinen, S. Weiss, P. Fauchet, and J. Sipe, "Optical sensor based on resonant porous silicon structures," Opt. Express 13, 3754-3764 (2005). [CrossRef] [PubMed]
  4. H. Arwin, M. Poksinski, and K. Johansen, "Total internal reflection ellipsometry: principles and applications," Appl. Opt. 43, 3028-3036 (2004). [CrossRef] [PubMed]
  5. A. Nabok, A. Tsargorodskaya, A. Holloway, N. Starodub, A. Demchenko, and O. Gojster, "Registration of low molecular weight environmental toxins with total internal reflection ellipsometry," Sensors 3, 1195-1198 (2004). [CrossRef]
  6. B. Liedberg, C. Nylander, and I. Lunderström, "Biosensing with surface plasmon resonance - how it all started," Biosens. Bioelectron. 10, 653-742 (1995). [CrossRef]
  7. B. Luff, J. Wilkinson, J. Piehler, U. Hollenbach, J. Ingenhoff, and N. Fabricius, "Integrated Optical Mach-Zehnder Biosensor," J. Lightwave Technol. 16, 583-592 (1998). [CrossRef]
  8. S. Wang and R. Magnusson, "Theory and applications of guided-mode resonance filters," Appl. Opt. 32, 2606-2613 (1993). [CrossRef] [PubMed]
  9. C. Mateus, M. Huang, C. Chang-Hasnain, J. Foley, R. Beatty, P. Li, and B. Cunningham, "Ultra-sensitive immunoassay using VCSEL detection system," Electron. Lett. 40, 649-651 (2004). [CrossRef]
  10. B. Lin, J. Qiu, J. Gerstenmeier, P. Li, H. Pien, J. Pepper, and B. Cunningham, "A label-free optical technique for detecting small molecule interactions," Biosens. Bioelectron. 17, 827-834 (2002). [CrossRef] [PubMed]
  11. S. Wang, R. Magnusson, J. Bagby, and M. Moharam, "Guided-mode resonances in planar dielectric-layer diffraction gratings," J. Opt. Soc. Am. A 8, 1470-1474 (1990). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited