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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 8 — Aug. 10, 2007

Quantification of optical Doppler broadening and optical path lengths of multiply scattered light by phase modulated low coherence interferometry

B. Varghese, V. Rajan, T. G. van Leeuwen, and W. Steenbergen  »View Author Affiliations


Optics Express, Vol. 15, Issue 15, pp. 9157-9165 (2007)
http://dx.doi.org/10.1364/OE.15.009157


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Abstract

We show experimental validation of a novel technique to measure optical path length distributions and path length resolved Doppler broadening in turbid media for different reduced scattering coefficients and anisotropies. The technique involves a phase modulated low coherence Mach-Zehnder interferometer, with separate fibers for illumination and detection. Water suspensions of Polystyrene microspheres with high scattering and low absorption levels are used as calibrated scattering phantoms. The path length dependent diffusion broadening or Doppler broadening of scattered light is shown to agree with Diffusive Wave Spectroscopy within 5%. The optical path lengths are determined experimentally from the zero order moment of the phase modulation peak around the modulation frequency in the power spectrum and the results are validated with Monte Carlo simulations.

© 2007 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 22, 2007
Revised Manuscript: July 5, 2007
Manuscript Accepted: July 9, 2007
Published: July 11, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
B. Varghese, V. Rajan, T. G. van Leeuwen, and W. Steenbergen, "Quantification of optical Doppler broadening and optical path lengths of multiply scattered light by phase modulated low coherence interferometry," Opt. Express 15, 9157-9165 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-15-9157


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References

  1. A. P. Shepherd and P. Å. Öberg, Laser-Doppler Blood Flowmetry (Kluwer Academic, Boston, 1990).
  2. A. Liebert, M. Leahy and R. Maniewski, "Multichannel laser-Doppler probe for blood perfusion measurements with depth discrimination," Med. Bio. Eng. Comp 36, 740-747 (1998). [CrossRef]
  3. F. Morales, R. Graaff, A. J. Smit, R. Gush, and G. Rakhorst, "The influence of probe fibre distance on laser Doppler perfusion monitoring measurements," Microcirculation 10, 433-441 (2003). [PubMed]
  4. M. Larsson, W. Steenbergen, and T. Strömberg, "Influence of optical properties and fibre separation on laser doppler flowmetry," J.Biomed. Opt. 7, 236-243 (2001). [CrossRef]
  5. A. Liebert, M. Leahy and R. Maniewski, "A calibration standard for laser-Doppler perfusion measurements," Rev. Sci. Inst. 66, 5169-5173 (1995). [CrossRef]
  6. A. Liebert, P. Lukasiewicz, D. Boggett and R. Maniewski, "Optoelectronic standardization of laser doppler perfusion monitors," 70, 1352-1354 (1999).
  7. W. Steenbergen and F. F. M. de Mul, "New optical tissue phantom and its use for studying laser Doppler blood flowmetry," Proc. SPIE 3196, 12 (1997). [CrossRef]
  8. E. Gratton and M. Limkerman, "A continuously variable frequency cross-correlation phase fluorometer with picosecond resolution," Biophys. J 44, 315-324 (1983). [CrossRef] [PubMed]
  9. B. Chance, J. S. Leigh, H. Miyake, D. S. Smith, S. Nioka, R. Greenfeld, M. Finander, K. Kaufmann, W. Levy, M. Young, P. Cohen, H. Yoshioka, and R. Boretsky, "Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain," Proc. Natl. Acad. Sci. 85, 4971-4975 (1988). [CrossRef] [PubMed]
  10. K. K. Bizheva, A. M. Siegel, and D. A. Boas, "Path-length-resolved dynamic light scattering in highly scattering random media: The transition to diffusing wave spectroscopy," Phys. Rev. E 58, 7664-7667 (1998). [CrossRef]
  11. A. Wax, C. Yang, R. R. Dasari, and M. S. Feld, "Path-length-resolved dynamic light scattering: modeling the transition from single to diffusive scattering," Appl. Opt. 40, 4222-4227 (2001). [CrossRef]
  12. A. L. Petoukhova, W. Steenbergen, and F. F. M. de Mul, "Path-length distribution and path-length resolved Doppler measurements of multiply scattered photons by use of low-coherence interferometer," Opt. Lett. 26, 1492-1494 (2001). [CrossRef]
  13. A. L. Petoukhova, W. Steenbergen, T. G. van Leeuwen and F. F. M. de Mul, "Effects of absorption on coherence domain path length resolved dynamic light scattering in the diffuse regime," Appl. Phys. Lett. 81, 595-597 (2002). [CrossRef]
  14. B. Varghese, V. Rajan, T. G. Van Leeuwen, and W. Steenbergen, "Path length resolved measurements of multiple scattered photons in static and dynamic turbid media using phase modulated low coherence interferometry," J. Biomed. Opt. 12, 024020 (2007). [CrossRef] [PubMed]
  15. G. Maret and P. E. Wolf, 'Multiple light-scattering from disordered media - the effect of Brownian motion of scatterers," Z. Phys. B 65, 409 (1987). [CrossRef]
  16. D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, Diffusing-wave spectroscopy Phys. Rev. Lett. 60, 1134-1137 (1988). [CrossRef] [PubMed]
  17. P. J. Berne and R. Pecora, Dynamic Light Scattering (Wiley, New York, 1976).
  18. R. Pecora, Dynamic light scattering: Applications of photon correlation spectroscopy (Plenum, New York, 1985).
  19. A. Ishimaru, Wave Propagation and Scattering in Random Media (IEEE Press, Piscataway, 1997).
  20. D. J. Durian, "Accuracy of diffusing-wave spectroscopy theories," Phys. Rev. E 51, 3350 (1995). [CrossRef]
  21. P. D. Kaplan, M. H. Kap, A.G. Yodh, and D. J. Pine, "Geometric constraints for the design of diffusing-wave spectroscopy experiments," Appl. Opt. 32, 3828 (1993). [PubMed]
  22. P. A. Lemieux, M. U. Vera, and D. J. Durian, "Diffusing-light spectroscopies beyond the diffusion limit: The role of ballistic transport and anisotropic scattering," Phys. Rev. E 57, 4498 (1998). [CrossRef]
  23. B. B. Das, F. Liu, and R. R. Alfano, Vol. 2 of Trends in Optics and Photonics, 41-44 (1996).
  24. I. Freund, M. Kaveh, and M. Rosenbluh, 'Dynamic multiple scattering: Ballistic photons and the breakdown of the photon-diffusion approximation,' Phys. Rev. Lett. 60, 1130-1133 (1988). [CrossRef] [PubMed]
  25. K. M. Yoo, F. Liu, and R. R. Alfano, "When does the diffusion approximation fail to describe photon transport in random media," Phys. Rev. Lett. 64, 2647-2650 (1990). [CrossRef] [PubMed]
  26. R. Carminati, R. Elaloufi, and J. J. Greffet, "Beyond the diffusing-wave spectroscopy model for the temporal fluctuations of scattered light," Phys. Rev. Lett. 92, 213903 (2004). [CrossRef] [PubMed]
  27. F. F. M. de Mul, M. H. Koelink, M. L. Kok, P. J. Harmsma, J. Greve, R. Graaff, and J. G. Aarnoudse, "Laser doppler velocimetry and Monte Carlo simulations on models for blood perfusion in tissue," Appl. Opt. 34, 6595-6611 (1995). [CrossRef] [PubMed]
  28. A. G. Yodh, P. D, Kaplan, and D. J.Pine, "Pulsed diffusing-wave spectroscopy: High resolution through nonlinear optical gating," Phys. Rev. B 42, 4744 (1990). [CrossRef]

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