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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 9 — Sep. 26, 2007

Image reconstruction in quantitative X-ray phase-contrast imaging employing multiple measurements

Cheng-Ying Chou, Yin Huang, Daxin Shi, and Mark A. Anastasio  »View Author Affiliations

Optics Express, Vol. 15, Issue 16, pp. 10002-10025 (2007)

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X-ray phase-contrast imaging is a technique that aims to reconstruct the projected absorption and refractive index distributions of an object. One common feature of reconstruction formulas for phase-contrast imaging is the presence of isolated Fourier domain singularities, which can greatly amplify the noise levels in the estimated Fourier domain and lead to noisy and/or distorted images in spatial domain. In this article, we develop a statistically optimal reconstruction method that employs multiple (>2) measurement states to mitigate the noise amplification effects due to singularities in the reconstruction formula. Computer-simulation studies are carried out to quantitatively and systematically investigate the developed method, within the context of propagation-based X-ray phase-contrast imaging. The reconstructed images are shown to possess dramatically reduced noise levels and greatly enhanced imaging contrast.

© 2007 Optical Society of America

OCIS Codes
(000.0000) General : General
(100.5070) Image processing : Phase retrieval
(110.7440) Imaging systems : X-ray imaging
(170.3010) Medical optics and biotechnology : Image reconstruction techniques

ToC Category:
Imaging Systems

Original Manuscript: February 5, 2007
Revised Manuscript: May 7, 2007
Manuscript Accepted: May 20, 2007
Published: July 25, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Cheng-Ying Chou, Yin Huang, Daxin Shi, and Mark A. Anastasio, "Image reconstruction in quantitative X-ray phase-contrast imaging employing multiple measurements," Opt. Express 15, 10002-10025 (2007)

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