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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 10 — Oct. 31, 2007

Noise pre-filtering techniques in fluorescence-enhanced optical tomography

B. Zhu, M. J. Eppstein, E. M. Sevick-Muraca, and A. Godavarty  »View Author Affiliations

Optics Express, Vol. 15, Issue 18, pp. 11285-11300 (2007)

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In this contribution, different measurement noise pre-filtering techniques were developed using frequency-domain fluorescence measurements of homogeneous breast phantoms. We demonstrated that implementing noise pre-filtering, based on modulation depth and measurement error in amplitude, can improve model match between experimental and simulated data under varying experimental conditions (target depths, 1–3 cm and fluorescence optical contrast, 1:0 and 100:1). Noise pre-filtering also improves the qualitative estimation of target(s) location in reconstructed images in deep target(s) when there was fluorescence in the background. Interestingly, decreases in model mismatch did not necessarily correlate with increases in reconstructed target accuracy. In addition, it was observed that pre-filtering measurement noise using different criteria can help differentiate target(s) from artifacts, thus possibly minimizing the false-positive cases in a clinical environment.

© 2007 Optical Society of America

OCIS Codes
(100.6950) Image processing : Tomographic image processing
(110.4280) Imaging systems : Noise in imaging systems
(260.2510) Physical optics : Fluorescence

ToC Category:
Image Processing

Original Manuscript: April 9, 2007
Revised Manuscript: May 23, 2007
Manuscript Accepted: July 9, 2007
Published: August 22, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

B. Zhu, M. J. Eppstein, E. M. Sevick-Muraca, and A. Godavarty, "Noise pre-filtering techniques in fluorescence-enhanced optical tomography," Opt. Express 15, 11285-11300 (2007)

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