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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 1 — Jan. 29, 2008

An optical tweezer actuated, nanoaperture-grid based Optofluidic Microscope implementation method

Xin Heng, Edward Hsiao, Demetri Psaltis, and Changhuei Yang  »View Author Affiliations

Optics Express, Vol. 15, Issue 25, pp. 16367-16375 (2007)

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We report a novel grid based Optofluidic Microscope (OFM) method where a closely spaced 2D grid of nanoapertures (diameter =100 nm, separation =2.5 µm) provided patterned illumination. We achieved a one-to-one mapping of the light transmissions through the nanoapertures onto a high-speed CCD camera. By optically tweezing a targeted sample across the grid in a controlled fashion and recording the time varying light reception from the nanoapertures, we were able to generate high-resolution images of the sample. The achievable resolution limit of the prototype was ~110 nm (Sparrow’s criterion) under optimal conditions. We demonstrated the technique by imaging polystyrene beads and pollen spores.

© 2007 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.1220) Imaging systems : Apertures
(130.0130) Integrated optics : Integrated optics

ToC Category:
Imaging Systems

Original Manuscript: September 12, 2007
Revised Manuscript: November 5, 2007
Manuscript Accepted: November 18, 2007
Published: November 26, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Xin Heng, Edward Hsiao, Demetri Psaltis, and Changhuei Yang, "An optical tweezer actuated, nanoaperture-grid based Optofluidic Microscope implementation method," Opt. Express 15, 16367-16375 (2007)

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