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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Two-dimensional silicon photonic crystal based biosensing platform for protein detection

Mindy Lee and Philippe M. Fauchet  »View Author Affiliations

Optics Express, Vol. 15, Issue 8, pp. 4530-4535 (2007)

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We theoretically and experimentally demonstrate an ultrasensitive two-dimensional photonic crystal microcavity biosensor. The device is fabricated on a silicon-on-insulator wafer and operates near its resonance at 1.58 μm. Coating the sensor internal surface with proteins of different sizes produces a different amount of resonance redshift. The present device can detect a molecule monolayer with a total mass as small as 2.5 fg. The device performance is verified by measuring the redshift corresponding to the binding of glutaraldehyde and bovine serum albumin (BSA). The experimental results are in good agreement with theory and with ellipsometric measurements performed on a flat oxidized silicon wafer surface.

© 2007 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(230.5750) Optical devices : Resonators

ToC Category:
Photonic Crystals

Original Manuscript: January 18, 2007
Revised Manuscript: March 23, 2007
Manuscript Accepted: March 23, 2007
Published: April 3, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Mindy R. Lee and Philippe M. Fauchet, "Two-dimensional silicon photonic crystal based biosensing platform for protein detection," Opt. Express 15, 4530-4535 (2007)

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