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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Three-dimensional scheme for time-domain fluorescence molecular tomography based on Laplace transforms with noise-robust factors

Limin Zhang, Feng Gao, Huiyuan He, and Huijuan Zhao  »View Author Affiliations


Optics Express, Vol. 16, Issue 10, pp. 7214-7223 (2008)
http://dx.doi.org/10.1364/OE.16.007214


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Abstract

As a visualizing and quantitative method, Fluorescence Molecular Tomography (FMT) has many potential applications in biomedical field and its three-dimensional (3D) implementation is needed in both theory and practice. In this paper, we propose a 3D scheme for time-domain FMT within the normalized Born-ratio formulation. A finite element method solution to the Laplace transformed time-domain coupled diffusion equations is employed as the forward model, and the resultant linear inversions at two distinct transform-factors are solved with an algebraic reconstruction technique to separate fluorescent yield and lifetime images. The algorithm is validated using simulated data for 3D cylinder phantoms, and the spatial resolution and quantitativeness of the reconstruction assessed. We demonstrate that the proposed approach can accurately retrieve the positions and shapes of the targets with high spatial resolution and quantitative accuracy, and tolerate a signal-to-noise ratio down to 25dB by appropriately choosing the transform factors.

© 2008 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 4, 2008
Revised Manuscript: March 13, 2008
Manuscript Accepted: April 29, 2008
Published: May 5, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Limin Zhang, Feng Gao, Huiyuan He, and Huijuan Zhao, "Three-dimensional scheme for time-domain fluorescence molecular tomography based on Laplace transforms with noise-robust factors," Opt. Express 16, 7214-7223 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-10-7214


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