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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction

Robert J. Zawadzki, Barry Cense, Yan Zhang, Stacey S. Choi, Donald T. Miller, and John S. Werner  »View Author Affiliations


Optics Express, Vol. 16, Issue 11, pp. 8126-8143 (2008)
http://dx.doi.org/10.1364/OE.16.008126


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Abstract

We have developed an improved adaptive optics - optical coherence tomography (AO-OCT) system and evaluated its performance for in vivo imaging of normal and pathologic retina. The instrument provides unprecedented image quality at the retina with isotropic 3D resolution of 3.5×3.5×3.5 µm3. Critical to the instrument’s resolution is a customized achromatizing lens that corrects for the eye’s longitudinal chromatic aberration and an ultra broadband light source (Δλ=112nm λ0=~836 nm). The eye’s transverse chromatic aberrations is modeled and predicted to be sufficiently small for the imaging conditions considered. The achromatizing lens was strategically placed at the light input of the AO-OCT sample arm. This location simplifies use of the achromatizing lens and allows straightforward implementation into existing OCT systems. Lateral resolution was achieved with an AO system that cascades two wavefront correctors, a large stroke bimorph deformable mirror (DM) and a micro-electromechanical system (MEMS) DM with a high number of actuators. This combination yielded diffraction-limited imaging in the eyes examined. An added benefit of the broadband light source is the reduction of speckle size in the axial dimension. Additionally, speckle contrast was reduced by averaging multiple B-scans of the same proximal patch of retina. The combination of improved micron-scale 3D resolution, and reduced speckle size and contrast were found to significantly improve visibility of microscopic structures in the retina.

© 2008 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.1000) Optical design and fabrication : Aberration compensation

ToC Category:
Imaging Systems

History
Original Manuscript: March 24, 2008
Revised Manuscript: May 16, 2008
Manuscript Accepted: May 17, 2008
Published: May 20, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Robert J. Zawadzki, Barry Cense, Yan Zhang, Stacey S. Choi, Donald T. Miller, and John S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-11-8126


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