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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 8 — Aug. 18, 2008

Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: an in vitro study

Q. Song, R. Risco, M. Latina, F. Berthiaume, Y. Nahmias, and M. L. Yarmush  »View Author Affiliations

Optics Express, Vol. 16, Issue 14, pp. 10518-10528 (2008)

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This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

© 2008 Optical Society of America

OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 4, 2008
Revised Manuscript: May 7, 2008
Manuscript Accepted: June 9, 2008
Published: June 30, 2008

Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics

Q. Song, R. Risco, M. Latina, F. Berthiaume, Y. Nahmias, and M. L. Yarmush, "Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: an in vitro study," Opt. Express 16, 10518-10528 (2008)

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