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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 9 — Sep. 8, 2008

Algorithm and simulation for analysis of bioimages obtained by aperture diffraction based optical MEMS

Xiaodong Zhou, Daniel Puiu Poenar, Kai Yu Liu, Man Siu Tse, Chew-Kiat Heng, Swee Ngin Tan, and Nan Zhang  »View Author Affiliations


Optics Express, Vol. 16, Issue 16, pp. 11937-11953 (2008)
http://dx.doi.org/10.1364/OE.16.011937


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Abstract

This paper proposes a novel method to detect transparent living cells in a transparent microfluidic chamber by optical diffraction of an aperture or an aperture array. Through the analysis of the far-field diffraction pattern, one of the parameters of the cells, including the size, refractive index, or position, can be extracted by the analysis software developed in this paper. Calculations are carried out to discuss the key issues of this MEMS device, and our simulation is verified by diffraction patterns of transparent microparticles on fabricated apertures, recorded via a digital camera

© 2008 Optical Society of America

OCIS Codes
(050.1970) Diffraction and gratings : Diffractive optics
(230.4000) Optical devices : Microstructure fabrication

ToC Category:
Diffraction and Gratings

History
Original Manuscript: May 28, 2008
Revised Manuscript: July 22, 2008
Manuscript Accepted: July 22, 2008
Published: July 25, 2008

Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Xiaodong Zhou, Daniel Puiu Poenar, Kai Yu Liu, Man Siu Tse, Chew-Kiat Heng, Swee Ngin Tan, and Nan Zhang, "Algorithm and simulation for analysis of bio-images obtained by aperture diffraction based optical MEMS," Opt. Express 16, 11937-11953 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-16-11937


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