OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 11 — Oct. 22, 2008

Fast time-domain diffuse optical tomography using pseudorandom bit sequences

Weirong Mo and Nanguang Chen  »View Author Affiliations


Optics Express, Vol. 16, Issue 18, pp. 13643-13650 (2008)
http://dx.doi.org/10.1364/OE.16.013643


View Full Text Article

Enhanced HTML    Acrobat PDF (196 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved signal can be retrieved very quickly by demodulation with the reference signal. The system impulse response has a full width at half maximum around 800 picoseconds and the 2-dimentional maps of optical properties can be obtained within a few seconds. The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection.

© 2008 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 23, 2008
Revised Manuscript: August 12, 2008
Manuscript Accepted: August 18, 2008
Published: August 20, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Weirong Mo and Nanguang Chen, "Fast time-domain diffuse optical tomography using pseudorandom bit sequences," Opt. Express 16, 13643-13650 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-18-13643


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008). [CrossRef]
  2. L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007). [CrossRef] [PubMed]
  3. A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006). [CrossRef] [PubMed]
  4. J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," Euro. Rad. 17, 2926-2933 (2007). [CrossRef]
  5. T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006). [CrossRef] [PubMed]
  6. M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006). [CrossRef] [PubMed]
  7. G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006). [CrossRef] [PubMed]
  8. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003). [CrossRef] [PubMed]
  9. J. M. Yang, Y. H. Han, G. Yoon, B. S. Ahn, B. C. Lee, and K. S. Soh, "In vivo 783-channel diffuse reflectance imaging system and its application," Appl. Opt. 46, 5991-6003 (2007). [CrossRef] [PubMed]
  10. M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).
  11. F. Gao, H. J. Zhao, and Y. Yamada, "Improvement of image quality in diffuse optical tomography by use of full time-resolved data," Appl. Opt. 41, 778-791 (2002). [CrossRef] [PubMed]
  12. W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005). [CrossRef]
  13. F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000). [CrossRef]
  14. H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999). [CrossRef]
  15. H. Zhao, F. Gao, Y. Tanikawa, K. Homma, and Y. Yamada, "Time-resolved diffuse optical tomographic imaging for the provision of both anatomical and functional information about biological tissue," Appl. Opt. 44, 1905-1916 (2005). [CrossRef] [PubMed]
  16. C. V. Zint,W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak camera: a multidetector for diffuse optical tomography," Appl. Opt. 42, 3313-3320 (2003). [CrossRef] [PubMed]
  17. J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995). [CrossRef] [PubMed]
  18. N. G. Chen and Q. Zhu, "Time-resolved optical measurements with spread spectrum excitations," Opt. Lett. 27, 1806-1808 (2002). [CrossRef]
  19. N. G. Chen and Q. Zhu, "Time-resolved diffusive optical imaging using pseudo-random bit sequences," Opt. Express 11, 3445-3454 (2003), http://www.opticsexpress.org/abstract.cfm?uri=OE-11-25-3445. [CrossRef] [PubMed]
  20. W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990). [CrossRef]
  21. J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006). [CrossRef] [PubMed]
  22. M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995). [CrossRef] [PubMed]
  23. M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2337 (1996). [CrossRef]
  24. D. A. Boas, T. Gaudette, and S. R. Arridge, "Simultaneous imaging and optode calibration with diffuse optical tomography," Opt. Express 8, 263-270 (2001), www.opticsexpress.org/abstract.cfm?URI=OPEX-8-5-263. [CrossRef] [PubMed]
  25. J. Wu, "Convolution picture of the boundary conditions in photon migration and its implications in time-resolved optical imaging of biological tissues," J. Opt. Soc. Am. A 14, 280-287 (1997). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 
Fig. 4.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited