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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 11 — Oct. 22, 2008

Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding

D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid  »View Author Affiliations


Optics Express, Vol. 16, Issue 19, pp. 15137-15148 (2008)
http://dx.doi.org/10.1364/OE.16.015137


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Abstract

We demonstrate folded waveguide ring resonators for biomolecular sensing. We show that extending the ring cavity length increases the resonator quality factor, and thereby enhances the sensor resolution and minimum level of detection, while at the same time relaxing the tolerance on the coupling conditions to provide stable and large resonance contrast. The folded spiral path geometry allows a 1.2 mm long ring waveguide to be enclosed in a 150 µm diameter sensor area. The spiral cavity resonator is used to monitor the streptavidin protein binding with a detection limit of ~3 pg/mm2, or a total mass of ~5 fg. The real time measurements are used to analyze the kinetics of biotin-streptavidin binding.

© 2008 Optical Society of America

OCIS Codes
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(220.0220) Optical design and fabrication : Optical design and fabrication
(230.5750) Optical devices : Resonators

ToC Category:
Integrated Optics

History
Original Manuscript: June 25, 2008
Revised Manuscript: August 30, 2008
Manuscript Accepted: September 8, 2008
Published: September 11, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Citation
D. X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, "Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding," Opt. Express 16, 15137-15148 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-19-15137


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