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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 11 — Oct. 22, 2008

Investigation of diffuse correlation spectroscopy in multi-layered media including the human head

Louis Gagnon, Michėle Desjardins, Julien Jehanne-Lacasse, Louis Bherer, and Frédéric Lesage  »View Author Affiliations


Optics Express, Vol. 16, Issue 20, pp. 15514-15530 (2008)
http://dx.doi.org/10.1364/OE.16.015514


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Abstract

In this work, diffuse correlation spectroscopy (DCS) is explored in multi-layered geometries. A quantitative comparison of an homogeneous versus a two-layered model efficiencies to recover flow changes is presented. By simulating a realistic human head with MRI anatomical data, we show that the two-layered model allows distinction between changes in superficial layers and brain. We also show that the two-layered model provides a better estimate of the flow change than the homogeneous one. Experimental measurements with a two-layered dynamical phantom confirm the ability of the two-layered analytical model to distinguish flow increase in each layer.

© 2008 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 15, 2008
Revised Manuscript: September 10, 2008
Manuscript Accepted: September 12, 2008
Published: September 17, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Louis Gagnon, Michèle Desjardins, Julien Jehanne-Lacasse, Louis Bherer, and Frédéric Lesage, "Investigation of diffuse correlation spectroscopy in multi-layered media including the human head," Opt. Express 16, 15514-15530 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-20-15514


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