OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 11 — Oct. 22, 2008

Quantitative spectroscopic imaging for noninvasive early cancer detection

Chung-Chieh Yu, Condon Lau, Geoff O’Donoghue, Jelena Mirkovic, Sasha McGee, Luis Galindo, Alphi Elackattu, Elizabeth Stier, Gregory Grillone, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Express, Vol. 16, Issue 20, pp. 16227-16239 (2008)
http://dx.doi.org/10.1364/OE.16.016227


View Full Text Article

Enhanced HTML    Acrobat PDF (2796 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.

© 2008 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 25, 2008
Revised Manuscript: September 18, 2008
Manuscript Accepted: September 22, 2008
Published: September 26, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Chung-Chieh Yu, Condon Lau, Geoffrey O'Donoghue, Jelena Mirkovic, Sasha McGee, Luis Galindo, Alphi Elackattu, Elizabeth Stier, Gregory Grillone, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld, "Quantitative spectroscopic imaging for non-invasive early cancer detection," Opt. Express 16, 16227-16239 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-20-16227


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. H. Yoon, A. Martin, R. Benamouzig, E. Longchampt, J. Deyra, S. Chaussade, and A. Grp, "Inter-observer agreement on histological diagnosis of colorectal polyps: the APACC study," Gastroenterol. Clin. Et Biol. 26, 220-224 (2002).
  2. W. G. McCluggage, M. Y. Walsh, C. M. Thornton, P. W. Hamilton, A. Date, L. M. Caughley, and H. Bharucha, "Inter- and intra-observer variation in the histopathological reporting of cervical squamous intraepithelial lesions using a modified Bethesda grading system," Br. J. Obstet. Gynaecol. 105, 206-210 (1998). [CrossRef] [PubMed]
  3. S. M. Ismail, A. B. Colclough, J. S. Dinnen, D. Eakins, D. M. D. Evans, E. Gradwell, J. P. Osullivan, J. M. Summerell, and R. Newcombe, "Intrapathologist and Interpathologist Variation in Reporting Cervical Intra-Epithelial Neoplasia and Factors Associated with Disagreement," J. Pathol. 160, A176-A176 (1990).
  4. B. J. Reid, R. C. Haggitt, C. E. Rubin, G. Roth, C. M. Surawicz, G. Vanbelle, K. Lewin, W. M. Weinstein, D. A. Antonioli, H. Goldman, W. Macdonald, and D. Owen, "Observer Variation in the Diagnosis of Dysplasia in Barretts Esophagus," Hum. Pathol. 19, 166-178 (1988). [CrossRef] [PubMed]
  5. I. Georgakoudi, E. E. Sheets, M. G. Muller, V. Backman, C. P. Crum, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo," Am. J. Obstet. Gynecol. 186, 374-382 (2002). [CrossRef] [PubMed]
  6. J. A. Freeberg, D. M. Serachitopol, N. McKinnon, R. Price, E. N. Atkinson, D. D. Cox, C. MacAulay, R. Richards-Kortum, M. Follen, and B. Pikkula, "Fluorescence and reflectance device variability throughout the progression of a phase II clinical trial to detect and screen for cervical neoplasia using a fiber optic probe," J. Biomed. Opt. 12, 034015 (2007). [CrossRef] [PubMed]
  7. S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, "Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer," J. Biomed. Opt. 10, 024031 (2005). [CrossRef] [PubMed]
  8. M. F. Mitchell, S. B. Cantor, N. Ramanujam, G. Tortolero-Luna, and R. Richards-Kortum, "Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix," Obstet. Gynecol. 93, 462-470 (1999). [CrossRef] [PubMed]
  9. M. G. Muller, T. A. Valdez, I. Georgakoudi, V. Backman, C. Fuentes, S. Kabani, N. Laver, Z. M. Wang, C. W. Boone, R. R. Dasari, S. M. Shapshay, and M. S. Feld, "Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma," Cancer 97, 1681-1692 (2003). [CrossRef] [PubMed]
  10. D. C. G. de Veld, M. Skurichina, M. J. H. Wities, R. P. W. Duin, H. J. C. M. Sterenborg, and J. L. N. Roodenburg, "Autofluorescence and diffuse reflectance spectroscopy for oral oncology," Lasers Surg. Med. 36, 356-364 (2005). [CrossRef] [PubMed]
  11. A. Gillenwater, R. Jacob, R. Ganeshappa, B. Kemp, A. K. El-Naggar, J. L. Palmer, G. Clayman, M. F. Mitchell, and R. Richards-Kortum, "Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence," Arch. Otolaryngol. Head Neck Surg. 124, 1251-1258 (1998). [PubMed]
  12. D. L. Heintzelman, U. Utzinger, H. Fuchs, A. Zuluaga, K. Gossage, A. M. Gillenwater, R. Jacob, B. Kemp, and R. R. Richards-Kortum, "Optimal excitation wavelengths for in vivo detection of oral neoplasia using fluorescence spectroscopy," Photochem. Photobiol. 72, 103-113 (2000). [CrossRef] [PubMed]
  13. S. K. Majumder, S. K. Mohanty, N. Ghosh, P. K. Gupta, D. K. Jain, and F. Khan, "A pilot study on the use of autofluorescence spectroscopy for diagnosis of the cancer of human oral cavity," Curr. Sci. 79, 1089-1094 (2000).
  14. A. Amelink, O. P. Kaspers, H. J. C. M. Sterenborg, J. E. van der Wal, J. L. N. Roodenburg, and M. J. H. Witjes, "Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy," Oral Oncol. 44, 65-71 (2008). [CrossRef]
  15. I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M. G. Muller, Q. Zhang, K. Badizadegan, D. Sun, G. A. Thomas, L. T. Perelman, and M. S. Feld, "Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus," Gastroenterology 120, 1620-1629 (2001). [CrossRef] [PubMed]
  16. T. Vo-Dinh, M. Panjehpour, and B. F. Overholt, "Laser-induced fluorescence for esophageal cancer and dysplasia diagnosis," Adv. Opt. Biopsy Opt. Mammography 838, 116-122 (1998).
  17. G. S. Fiarman, M. H. Nathanson, A. B. West, L. I. Deckelbaum, L. Kelly, and C. R. Kapadia, "Differences in Laser-Induced Autofluorescence between Adenomatous and Hyperplastic Polyps and Normal Colonic Mucosa by Confocal Microscopy," Dig. Dis. Sci. 40, 1261-1268 (1995). [CrossRef] [PubMed]
  18. M. P. L. Bard, A. Amelink, M. Skurichina, V. N. Hegt, R. P. W. Duin, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, "Optical spectroscopy for the classification of malignant lesions of the bronchial tree," Chest 129, 995-1001 (2006). [CrossRef] [PubMed]
  19. J. R. Mourant, I. J. Bigio, J. Boyer, R. L. Conn, T. Johnson, and T. Shimada, "Spectroscopic diagnosis of bladder cancer with elastic light scattering," Lasers Surg. Med. 17, 350-357 (1995). [CrossRef] [PubMed]
  20. G. Zonios, L. T. Perelman, V. M. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, "Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo," Appl. Opt. 38, 6628-6637 (1999). [CrossRef]
  21. M. G. Muller, I. Georgakoudi, Q. G. Zhang, J. Wu, and M. S. Feld, "Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption," Appl. Opt. 40, 4633-4646 (2001). [CrossRef]
  22. J. M. Benavides, S. Chang, S. Y. Park, R. Richards-Kortum, N. Mackinnon, C. MacAulay, A. Milbourne, A. Malpica, and M. Follen, "Multispectral digital colposcopy for in vivo detection of cervical cancer," Opt. Express. 11, 1223-1236 (2003). [CrossRef] [PubMed]
  23. T. Vo-Dinh, D. L. Stokes, M. B. Wabuyele, M. E. Martin, J. M. Song, R. Jagannathan, E. Michaud, R. J. Lee, and X. G. Pan, "A hyperspectral imaging system for in vivo optical diagnosis," IEEE Eng. Med. Biol. Mag. 23, 40-49 (2004). [CrossRef] [PubMed]
  24. K. T. Schomacker, T. M. Meese, C. S. Jiang, C. C. Abele, K. Dickson, S. T. Sum, and R. F. Flewelling, "Novel optical detection system for in vivo identification and localization of cervical intraepithelial neoplasia," J. Biomed. Opt. 11, 034009 (2006). [CrossRef]
  25. S. C. Gebhart, R. C. Thompson, and A. Mahadevan-Jansen, "Liquid-crystal tunable filter spectral imaging for brain tumor demarcation," Appl. Opt. 46, 1896-1910 (2007). [CrossRef] [PubMed]
  26. J. W. Tunnell, A. E. Desjardins, L. Galindo, I. Georgakoudi, S. A. McGee, J. Mirkovic, M. G. Mueller, J. Nazemi, F. T. Nguyen, A. Wax, Q. G. Zhang, R. R. Dasari, and M. S. Feld, "Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia," Technol. Cancer Res. Treat. 2, 505-514 (2003). [PubMed]
  27. C. D. Kuglin, and D. C. Hines, "The phase correlation image alignment method," in IEEE Int. Conf. on Cybernetics and Society (1975).
  28. J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, and I. J. Bigio, "Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms," Appl. Opt. 36, 949-957 (1997). [CrossRef] [PubMed]
  29. O. W. V. Assendelft, Spectrophotometry of Haemoglobin Derivatives (Royal Vangorcum, Assen, 1970).
  30. B. Rosner, Fundamentals of biostatistics, 6th ed. (Thomson-Brooks/Cole, Belmont, CA, 2006), p. 868.
  31. H. J. Vanstaveren, C. J. M. Moes, J. Vanmarle, S. A. Prahl, and M. J. C. Vangemert, "Light-Scattering in Intralipid-10-Percent in the Wavelength Range of 400-1100 Nm," Appl. Opt. 30, 4507-4514 (1991). [CrossRef]
  32. L. V. Wang, and H.-i. Wu, Biomedical Optics: Principles and Imaging (Wiley, 2007).
  33. R. Kalluri, and M. Zeisberg, "Fibroblasts in cancer," Nat. Rev. Cancer 6, 392-401 (2006). [CrossRef] [PubMed]
  34. H. Nagase, and J. F. Woessner, "Matrix metalloproteinases," J. Biol. Chem. 274, 21491-21494 (1999). [CrossRef] [PubMed]
  35. B. Chance, P. Cohen, F. Jobsis, and B. Schoener, "Intracellular oxidation-reduction states in vivo," Science 137, 499-508 (1962). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited