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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 12 — Dec. 1, 2008

Nonlinear-microscopy optical-pulse sources based on mode-locked semiconductor lasers

H. Yokoyama, A. Sato, H. -C. Guo, K. Sato, M. Mure, and H. Tsubokawa  »View Author Affiliations


Optics Express, Vol. 16, Issue 22, pp. 17752-17758 (2008)
http://dx.doi.org/10.1364/OE.16.017752


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Abstract

We developed picosecond optical-pulse sources suitable for multiphoton microscopy based on mode-locked semiconductor lasers. Using external-cavity geometry, stable hybrid mode locking was achieved at a repetition rate of 500 MHz. Semiconductor optical amplifiers driven by synchronized electric pulses reached subharmonic optical-pulse repetition rates of 1–100 MHz. Two-stage Yb-doped fiber amplifiers produced optical pulses of 2 ps duration, with a peak power of a few kilowatts at a repetition rate of 10 MHz. These were employed successfully for nonlinear-optic bio-imaging using two-photon fluorescence, second-harmonic generation, and sum-frequency generation of synchronized two-color pulses.

© 2008 Optical Society of America

OCIS Codes
(140.4480) Lasers and laser optics : Optical amplifiers
(140.5960) Lasers and laser optics : Semiconductor lasers
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4180) Nonlinear optics : Multiphoton processes
(320.7090) Ultrafast optics : Ultrafast lasers

ToC Category:
Lasers and Laser Optics

History
Original Manuscript: August 7, 2008
Revised Manuscript: September 18, 2008
Manuscript Accepted: September 20, 2008
Published: October 17, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
H. Yokoyama, A. Sato, H. -C. Guo, K. Sato, M. Mure, and H. Tsubokawa, "Nonlinear-microscopy optical-pulse sources based on mode-locked semiconductor lasers," Opt. Express 16, 17752-17758 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-22-17752


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References

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