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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 12 — Dec. 1, 2008

Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes

Hyun Keol Kim, Uwe J. Netz, Jürgen Beuthan, and Andreas H. Hielscher  »View Author Affiliations


Optics Express, Vol. 16, Issue 22, pp. 18082-18101 (2008)
http://dx.doi.org/10.1364/OE.16.018082


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Abstract

In frequency-domain optical tomography (FDOT) the quality of the reconstruction result is affected by the choice of the source-modulation frequency. In general the accuracy of the reconstructed image should improve as the source-modulation frequency increases. However, this is only true for noise-free data. Experimental data is typically corrupted by noise and the accuracy is compromised. Assuming the validity of the widely used shot noise model, one can show that the signal-to-noise ratio (SNR) of the amplitude signal decreases with increasing frequency, whereas the SNR of the phase shift reaches peak values in the range between 400 MHz and 800 MHz. As a consequence, it can be assumed that there exists an optimal frequency for which the reconstruction accuracy would be highest. To determine optimal frequencies for FDOT, we investigate here the frequency dependence of optical tomographic reconstruction results using the frequency-domain equation of radiative transfer. We present numerical and experimental studies with a focus on small tissue volumes, as encountered in small animal and human finger imaging. Best reconstruction results were achieved in the 600–800 MHz frequency range.

© 2008 Optical Society of America

OCIS Codes
(060.2630) Fiber optics and optical communications : Frequency modulation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4090) Medical optics and biotechnology : Modulation techniques
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 9, 2008
Revised Manuscript: October 15, 2008
Manuscript Accepted: October 18, 2008
Published: October 21, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics
Interactive Science Publishing (2008) Optics Express

Citation
Hyun Keol Kim, Uwe J. Netz, Jürgen Beuthan, and Andreas H. Hielscher, "Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes," Opt. Express 16, 18082-18101 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-22-18082


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