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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 2 — Feb. 10, 2009

Design and demonstration of a small-animal upconversion imager

Christopher Salthouse, Scott Hildebrand, Ralph Weissleder, and Umar Mahmood  »View Author Affiliations

Optics Express, Vol. 16, Issue 26, pp. 21731-21737 (2008)

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This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4180) Nonlinear optics : Multiphoton processes

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 24, 2008
Revised Manuscript: November 19, 2008
Manuscript Accepted: November 21, 2008
Published: December 16, 2008

Virtual Issues
Vol. 4, Iss. 2 Virtual Journal for Biomedical Optics

Christopher Salthouse, Scott Hilderbrand, Ralph Weissleder, and Umar Mahmood, "Design and demonstration of a small-animal up-conversion imager," Opt. Express 16, 21731-21737 (2008)

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  1. B. Chakravarti, M. Louie, W. Ratanaprayul, A. Raval, S. Gallagher, and D. N. Chakravarti, "A highly uniform UV transillumination imaging system for quantitative analysis of nucleic acids and proteins," Proteomics 8, 1789-1797 (2008). [CrossRef] [PubMed]
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