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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 2 — Feb. 10, 2009

Design and demonstration of a small-animal upconversion imager

Christopher Salthouse, Scott Hildebrand, Ralph Weissleder, and Umar Mahmood  »View Author Affiliations


Optics Express, Vol. 16, Issue 26, pp. 21731-21737 (2008)
http://dx.doi.org/10.1364/OE.16.021731


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Abstract

This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4180) Nonlinear optics : Multiphoton processes

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 24, 2008
Revised Manuscript: November 19, 2008
Manuscript Accepted: November 21, 2008
Published: December 16, 2008

Virtual Issues
Vol. 4, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Christopher Salthouse, Scott Hilderbrand, Ralph Weissleder, and Umar Mahmood, "Design and demonstration of a small-animal up-conversion imager," Opt. Express 16, 21731-21737 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-26-21731


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References

  1. B. Chakravarti, M. Louie, W. Ratanaprayul, A. Raval, S. Gallagher, and D. N. Chakravarti, "A highly uniform UV transillumination imaging system for quantitative analysis of nucleic acids and proteins," Proteomics 8, 1789-1797 (2008). [CrossRef] [PubMed]
  2. A. Wunder, C.-H. Tung, U. Muller-Ladner, R. Weissleder, and U. Mahmood, "In vivo imaging of protease activity in arthritis," Arthritis and Rheumatism 50, 2459-2465 (2004). [CrossRef] [PubMed]
  3. S. Andersson-Engels, C. Klinteberg, K. Svanberg, and S. Svanberg "In vivo fluorescence imaging for tissue diagnostics," Phys. Med. Bio. 42, 815-824 (1997). [CrossRef]
  4. R. Weissleder and V. Ntziachristos "Shedding light onto live molecular targets" Nature Medicine 9, 123-128 (2003). [CrossRef] [PubMed]
  5. P. L. A. M Corstjens, S. Li, M. Zuiderwijk, K. Kardos, W. R. Abrahms, R. S. Niedbla, and H. J. Tanke, "Infrared up-converting phosphors for bioassays," IEEE Proc. Nanobiotechnol. 152, 64-72 (2005). [CrossRef]
  6. Z. Chen, H. Chen, H. Hu, M. Yu, F. Li, Q. Zhang, Z. Zhou, T. Yi, and C. Huang, "Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphores as biological labels," JACS 130, 3023-3029 (2008). [CrossRef]
  7. K. Kuningas, H. Pakkila, T. Ukonaho, T. Rantanen, T. Lovgren, and T. Soukka, "Upconversion fluorescence enables homogeneous immunoassay in whole blood," Clin. Chem. 53, 145-146 (2007). [CrossRef] [PubMed]
  8. T. Rantanen, M.-L. Jarvenpaa, J. Vuojola, K. Kuningas, and T. Soukka, "Fluorescence-quenching-based enzyme-activity assay by using photon upconversion," Angew. Chem. Int. Ed. 47, 3811-3813 (2008). [CrossRef]
  9. S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, "In vivo and scanning electron microscopy imaging of upconverting nanophosphors in caenorhabditis elegans" Nano. Lett. 6, 169-174 (2006). [CrossRef] [PubMed]
  10. D. K. Chatterjee, A. J. Rufaihah, and Y. Zhang, "Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals," Biomaterials 29, 937-943 (2008). [CrossRef]
  11. American National Standard for Safe Use of Lasers ANSI Z136.1-2000 (American National Standard Institute, Orlando, Fl 2000).

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