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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography

Desmond C. Adler, Shu-Wei Huang, Robert Huber, and James G. Fujimoto  »View Author Affiliations


Optics Express, Vol. 16, Issue 7, pp. 4376-4393 (2008)
http://dx.doi.org/10.1364/OE.16.004376


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Abstract

The detection of a gold nanoparticle contrast agent is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography (OCT). A focused beam from a laser diode at 808 nm is modulated at frequencies of 500 Hz–60 kHz while irradiating a solution containing nanoshells. Because the nanoshells are designed to have a high absorption coefficient at 808 nm, the laser beam induces small-scale localized temperature oscillations at the modulation frequency. These temperature oscillations result in optical path length changes that are detected by a phase-sensitive, swept source OCT system. The OCT system uses a double-buffered Fourier domain mode locked (FDML) laser operating at a center wavelength of 1315 nm and a sweep rate of 240 kHz. High contrast is observed between phantoms containing nanoshells and phantoms without nanoshells. This technique represents a new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT.

© 2008 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(140.3600) Lasers and laser optics : Lasers, tunable
(160.4236) Materials : Nanomaterials

ToC Category:
Imaging Systems

History
Original Manuscript: January 9, 2008
Revised Manuscript: March 11, 2008
Manuscript Accepted: March 14, 2008
Published: March 17, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Desmond C. Adler, Shu-Wei Huang, Robert Huber, and James G. Fujimoto, "Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography," Opt. Express 16, 4376-4393 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-7-4376


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