OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Imaging complex structures with diffuse light

Soren D. Konecky, George Y. Panasyuk, Kijoon Lee, Vadim Markel, Arjun G. Yodh, and John C. Schotland  »View Author Affiliations


Optics Express, Vol. 16, Issue 7, pp. 5048-5060 (2008)
http://dx.doi.org/10.1364/OE.16.005048


View Full Text Article

Enhanced HTML    Acrobat PDF (387 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We use diffuse optical tomography to quantitatively reconstruct images of complex phantoms with millimeter sized features located centimeters deep within a highly-scattering medium. A non-contact instrument was employed to collect large data sets consisting of greater than 107 source-detector pairs. Images were reconstructed using a fast image reconstruction algorithm based on an analytic solution to the inverse scattering problem for diffuse light.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Imaging Systems

History
Original Manuscript: January 28, 2008
Revised Manuscript: March 24, 2008
Manuscript Accepted: March 24, 2008
Published: March 28, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Soren D. Konecky, George Y. Panasyuk, Kijoon Lee, Vadim Markel, Arjun G. Yodh, and John C. Schotland, "Imaging complex structures with diffuse light," Opt. Express 16, 5048-5060 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-7-5048


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. C. W. van Rossum and T. M. Nieuwenhuizen, "Multiple scattering of classical waves: microscopy, mesoscopy and diffusion," Rev. Mod. Phys. 71, 313-371 (1999). [CrossRef]
  2. A. Yodh and B. Chance, "Spectroscopy and imaging with diffuse light," Phys. Today 34-40 (1995). [CrossRef]
  3. S. R. Arridge, "Optical tomography in medical imaging," Inverse Problems 15, R41-R93 (1999). [CrossRef]
  4. A. P. Gibson, J. C. Hebden, and S. R. Arridge, "Recent advances in diffuse optical imaging," Phys. Med. Biol. 50, R1-R43 (2005). [CrossRef] [PubMed]
  5. S. B. Colak, M. B. van der Mark, G. W. Hooft, J. H. Hoogenraad, E. S. van der Linden, and F. A. Kuijpers, "Clinical optical tomography and NIR spectroscopy for breast cancer detection," IEEE J. Sel. Top. Quantum Electron. 5, 1143-1158 (1999). [CrossRef]
  6. D. J. Hawrysz and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using nearinfrared optical measurements and fluorescent contrast agants," Neoplasia 2, 388-417 (2000). [CrossRef]
  7. Y. Xu, X. J. Gu, L. L. Fajardo, and H. B. Jiang, "In vivo breast imaging with diffuse optical tomography based on higher-order diffusion equations," Appl. Opt. 42, 3163-3169 (2003). [CrossRef] [PubMed]
  8. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh, "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003). [CrossRef] [PubMed]
  9. Q. I. Zhu, M. M. Huang, N. G. Chen, K. Zarfos, B. Jagjivan, M. Kane, P. Hedge, and S. H. Kurtzman, "Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: Initial clinical results of 19 cases," Neoplasia 5, 379-388 (2003). [PubMed]
  10. X. Intes, J. Ripoll, Y. Chen, S. Nioka, A. G. Yodh, and B. Chance, "In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green," Med. Phys. 30, 1039-1047 (2003). [CrossRef] [PubMed]
  11. A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilacchio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Chorlton, R. H. Moore, D. B. Kopans, and D. A. Boas, "Tomographic optical breast imaging guided by three-dimensional mammography," Appl. Opt. 42, 5181-5190 (2003). [CrossRef] [PubMed]
  12. S. D. Jiang, B. W. Pogue, T. O. McBride, M. M. Doyley, S. P. Poplack, and K. D. Paulsen, "Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms," J. Electron. Imaging 12, 613-620 (2003). [CrossRef]
  13. D. A. Benaron, J. van Houten, D. C. Ho, S. D. Spilman, and D. K. Stevenson, "Imaging neonatal brain injury using light-based optical tomography," Pediatr. Res. 35, A378-A378 (1994).
  14. J. P. van Houten, W. F. Cheong, E. L. Kermit, T. R. Machold, D. K. Stevenson, and D. A. Benaron, "Clinical measurement of brain oxygenation and function using light-based optical tomography," Pediatr. Res. 39, 2273- 2273 (1996). [CrossRef]
  15. A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, "Three-dimensional optical tomography of hemodynamics in the human head," Opt. Express 9, 272-286 (2001). [CrossRef] [PubMed]
  16. G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002). [CrossRef] [PubMed]
  17. J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, "Three-dimensional optical tomography of the premature infant brain," Phys. Med. Biol. 47, 4155-4166 (2002). [CrossRef] [PubMed]
  18. J. C. Hebden, "Advances in optical imaging of the newborn infant brain," Psychophysiology 40, 501-510 (2003). [CrossRef] [PubMed]
  19. J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, "Volumetric diffuse optical tomography of brain activity," Opt. Lett. 28, 2061-2063 (2003). [CrossRef] [PubMed]
  20. A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, "Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation," Phys. Med. Biol. 48, 1391-1403 (2003). [CrossRef] [PubMed]
  21. G. Q. Yu, T. Durduran, D. Furuya, J. H. Greenberg, and A. G. Yodh, "Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics," Appl. Opt. 42, 2931-2939 (2003). [CrossRef] [PubMed]
  22. J. C. Schotland, "Continuous wave diffusion imaging," J. Opt. Soc. Am. A 14, 275-279 (1997). [CrossRef]
  23. V. A. Markel and J. C. Schotland, "Inverse scattering for the diffusion equation with general boundary conditions," Phys. Rev. E 64, R035,601 (2001). [CrossRef]
  24. V. A. Markel and J. C. Schotland, "The inverse problem in optical diffusion tomography. II. Inversion with boundary conditions," J. Opt. Soc. Am. A 19, 558-566 (2002). [CrossRef]
  25. V. A. Markel and J. C. Schotland, "Effects of sampling and limited data in optical tomography," Appl. Phys. Lett. 81, 1180-1182 (2002). [CrossRef]
  26. J. C. Schotland and V. A. Markel, "Inverse scattering with diffusing waves," J. Opt. Soc. Am. A 18, 2767-2777 (2001). [CrossRef]
  27. G. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 30, 409-411 (2005). [CrossRef] [PubMed]
  28. R. Schulz, J. Ripoll, and V. Ntziachristos, "Noncontact optical tomography of turbid media," Opt. Lett. 28, 1701- 1703 (2003). [CrossRef] [PubMed]
  29. Z.-M. Wang, G. Y. Panasyuk, V. A. Markel, and J. C. Schotland, "Experimental demonstration of an analytic method for image reconstruction in optical tomography with large data sets," Opt. Lett. 30, 3338-3340 (2005). [CrossRef]
  30. V. A. Markel, V. Mital, and J. C. Schotland, "The inverse problem in optical diffusion tomography. III. Inversion formulas and singular value decomposition," J. Opt. Soc. Am. A 20, 890-902 (2003). [CrossRef]
  31. V. A. Markel and J. C. Schotland, "Symmetries, inversion formulas and image reconstruction for optical tomography," Phys. Rev. E 70, 056,616 (2004). [CrossRef]
  32. R. Choe, "Diffuse Optical Tomography and Spectroscopy of Breast Cancer and Fetal Brain," Ph.D. thesis, University of Pennsylvania (2005).
  33. A. Ishimaru, Wave Propagation and Scattering in Random Media (IEEE Press, Piscataway, NJ, 1997).
  34. R. Aronson, "Boundary conditions for diffuse light," J. Opt. Soc. Am. A 12, 2532-2539 (1995). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited