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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 8 — Jul. 30, 2009

Quantitative phase-contrast tomography of a liquid phantom using a conventional x-ray tube source

Julia Herzen, Tilman Donath, Franz Pfeiffer, Oliver Bunk, Celestino Padeste, Felix Beckmann, Andreas Schreyer, and Christian David  »View Author Affiliations


Optics Express, Vol. 17, Issue 12, pp. 10010-10018 (2009)
http://dx.doi.org/10.1364/OE.17.010010


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Abstract

Over the last few years, differential phase-contrast x-ray computed tomography (PC-CT) using a hard x-ray grating interferometer and polychromatic x-ray tube sources has been developed. The method allows for simultaneous determination of the attenuation coefficient and the refractive index decrement distribution inside an object in three dimensions. Here we report experimental results of our investigation on the quantita-tiveness and accuracy of this method. For this study, a phantom consisting of several tubes filled with chemically well-defined liquids was built and measured in PC-CT. We find, that the measured attenuation coefficients and refractive index decrements closely match calculated, theoretical values. Moreover, the study demonstrates, how substances with similar attenuation coefficient or refractive index decrement, can be uniquely distinguished by the simultaneous, quantitative measurement of both quantities.

© 2009 Optical Society of America

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(110.3175) Imaging systems : Interferometric imaging
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Imaging Systems

History
Original Manuscript: March 11, 2009
Revised Manuscript: April 18, 2009
Manuscript Accepted: April 30, 2009
Published: May 29, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Julia Herzen, Tilman Donath, Franz Pfeiffer, Oliver Bunk, Celestino Padeste, Felix Beckmann, Andreas Schreyer, and Christian David, "Quantitative phase-contrast tomography of a liquid phantom using a conventional x-ray tube source," Opt. Express 17, 10010-10018 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-12-10010


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