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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 8 — Jul. 30, 2009

Optics InfoBase > Virtual Journal for Biomedical Optics > Volume 4 > Issue 8 > Page 10786

High temporal resolution OCT using image-based retrospective gating

Madhusudhana Gargesha, Michael W. Jenkins, David L. Wilson, and Andrew M. Rollins  »View Author Affiliations


Optics Express, Vol. 17, Issue 13, pp. 10786-10799 (2009)
http://dx.doi.org/10.1364/OE.17.010786


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Abstract

High temporal resolution OCT imaging is very advantageous for analyzing cardiac mechanics in the developing embryonic heart of small animals. An image-based retrospective gating technique is presented to increase the effective temporal resolution of an OCT system and to allow visualization of systolic dynamics in 3D. The gating technique employs image similarity measures for rearranging asynchronously acquired input data consisting of a time series of 2D images at each z position along the heart volume, to produce a time sequence of 3D volumes of the beating heart. The study includes a novel robust validation technique, which quantitatively evaluates the accuracy of the gating technique, in addition to visual evaluations by 2D multiplanar reformatting (MPR) and 3D volume rendering. The retrospective gating and validation is demonstrated on a stage 14 embryonic quail heart data set. Using the validation scheme, it is shown that the gating is accurate within a standard deviation of 4.7 ms, which is an order of magnitude shorter than the time interval during which systolic contraction (~50 ms) occurs in the developing embryo. This gating method has allowed, for the first time, clear visualization of systolic dynamics of the looping embryonic heart in 3D.

© 2009 OSA

OCIS Codes
(100.2960) Image processing : Image analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(110.4155) Imaging systems : Multiframe image processing

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 11, 2009
Revised Manuscript: April 27, 2009
Manuscript Accepted: May 3, 2009
Published: June 12, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Madhusudhana Gargesha, Michael W. Jenkins, David L. Wilson, and Andrew M. Rollins, "High temporal resolution OCT using image-based retrospective gating," Opt. Express 17, 10786-10799 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-13-10786


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