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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 8 — Jul. 30, 2009

Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses

Märta Lewander, Zuguang Guan, Katarina Svanberg, Sune Svanberg, and Tomas Svensson  »View Author Affiliations


Optics Express, Vol. 17, Issue 13, pp. 10849-10863 (2009)
http://dx.doi.org/10.1364/OE.17.010849


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Abstract

We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5×10-5 for oxygen and 5×10-4 for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy.

© 2009 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4940) Medical optics and biotechnology : Otolaryngology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6260) Spectroscopy : Spectroscopy, diode lasers
(300.6320) Spectroscopy : Spectroscopy, high-resolution

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 7, 2009
Revised Manuscript: May 4, 2009
Manuscript Accepted: May 5, 2009
Published: June 15, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Märta Lewander, Zuguang Guan, Katarina Svanberg, Sune Svanberg, and Tomas Svensson, "Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses," Opt. Express 17, 10849-10863 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-13-10849


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