OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 9 — Sep. 4, 2009

Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue

Zhiqiu Li, Venkataramanan Krishnaswamy, Scott C. Davis, Subhadra Srinivasan, Keith D. Paulsen, and Brian W. Pogue  »View Author Affiliations


Optics Express, Vol. 17, Issue 14, pp. 12043-12056 (2009)
http://dx.doi.org/10.1364/OE.17.012043


View Full Text Article

Enhanced HTML    Acrobat PDF (779 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A high frame-rate near-infrared (NIR) tomography system was created to allow transmission imaging of thick tissues with spectral encoding for parallel source implementation. The design was created to maximize tissue penetration through up to 10 cm of tissue, allowing eventual use in human imaging. Eight temperature-controlled laser diodes (LD) are used in parallel with 1.5 nm shifts in their lasing wavelengths. Simultaneous detection is achieved with eight high-resolution, CCD-based spectrometers that were synchronized to detect the intensities and decode their source locations from the spectrum. Static and dynamic imaging is demonstrated through a 64 mm tissue-equivalent phantom, with acquisition rates up to 20 frames per second. Imaging of pulsatile absorption changes through a 72 mm phantom was demonstrated with a 0.5 Hz varying object having only 1% effect upon the transmitted signal. This subtle signal change was used to show that while reconstructing the signal changes in a tissue may not be possible, image-guided recovery of the pulsatile change in broad regions of tissue was possible. The ability to image thick tissue and the capacity to image periodic changes in absorption makes this design well suited for tracking thick tissue hemodynamics in vivo during MR or CT imaging.

© 2009 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7160) Medical optics and biotechnology : Ultrafast technology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 18, 2009
Revised Manuscript: May 19, 2009
Manuscript Accepted: May 20, 2009
Published: July 2, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Zhiqiu Li, Venkataramanan Krishnaswamy, Scott C. Davis, Subhadra Srinivasan, Keith D. Paulsen, and Brian W. Pogue, "Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue," Opt. Express 17, 12043-12056 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-14-12043


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. C. H. Schmitz, M. Löcker, J. M. Lasker, A. H. Hielscher, and R. L. Barbour, “Instrumentation for fast functional optical tomography,” Rev. Sci. Instrum. 73(2), 429 (2002). [CrossRef]
  2. S. Fantini, M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, K. T. Moesta, P. M. Schlag, and M. Kaschke, “Frequency-domain optical mammography: edge effect corrections,” Med. Phys. 23(1), 149–157 (1996). [CrossRef]
  3. A. M. Siegel, J. J. A. Marota, and D. A. Boas, “Design and evaluation of a continuous-wave diffuse optical tomography system,” Opt. Express 4(8), 287–298 (1999).
  4. D. Piao, H. Dehghani, S. Jiang, S. Srinivasan, and B. W. Pogue, “Instrumentation for video-rate near-infrared diffuse optical tomography,” Rev. Sci. Instrum. 76(12), 124301 (2005). [CrossRef]
  5. Z. Li, V. Krishnaswamy, K. D. Paulsen, and B. W. Pogue, “Video-rate near infrared tomography for imaging thick tissue with dynamically varying absorption properties,” Proc. SPIE 7174, 71742G (2009). [CrossRef]
  6. S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008). [CrossRef]
  7. S. Jiang, B. W. Pogue, S. Srinivasan, S. Soho, S. P. Poplack, T. D. Tosteson, and K. D. Paulsen, “Assessment of the menstrual cycle upon total hemoglobin, water concentration and oxygen saturation in the female breast,” Proc. SPIE 4955, 342–348 (2003). [CrossRef]
  8. H. Dehghani, B. W. Pogue, S. P. Poplack, and K. D. Paulsen, “Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results,” Appl. Opt. 42(1), 135–145 (2003). [CrossRef]
  9. T. O. McBride, “Spectroscopic Reconstructed Near Infrared Tomographic Imaging for Breast Cancer Diagnosis,” (Dartmouth College, 2001). http://nir.thayer.dartmouth.edu/Downloads.html
  10. B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. STQE 9, 199–209 (2003).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited