OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 9 — Sep. 4, 2009

Terahertz pulsed spectroscopy of freshly excised human breast cancer

Philip C. Ashworth, Emma Pickwell-MacPherson, Elena Provenzano, Sarah E. Pinder, Anand D. Purushotham, Michael Pepper, and Vincent P. Wallace  »View Author Affiliations


Optics Express, Vol. 17, Issue 15, pp. 12444-12454 (2009)
http://dx.doi.org/10.1364/OE.17.012444


View Full Text Article

Enhanced HTML    Acrobat PDF (481 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The complex refractive indices of freshly excised healthy breast tissue and breast cancers collected from 20 patients were measured in the range of 0.15 – 2.0 THz using a portable terahertz pulsed transmission spectrometer. Histology was performed to classify the tissue samples as healthy adipose tissue, healthy fibrous breast tissue, or breast cancers. The average complex refractive index was determined for each group and it was found that samples containing cancer had a higher refractive index and absorption coefficient. The terahertz properties of the tissues were also used to simulate the impulse response functions expected when imaging breast tissue in a reflection geometry as in terahertz pulsed imaging (TPI). Our results indicate that both TPS and TPI can be used to distinguish between healthy adipose breast tissue, healthy fibrous breast tissue and breast cancer due to the differences in the fundamental optical properties.

© 2009 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6495) Spectroscopy : Spectroscopy, teraherz
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 4, 2009
Revised Manuscript: June 29, 2009
Manuscript Accepted: June 29, 2009
Published: July 20, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Philip C. Ashworth, Emma Pickwell-MacPherson, Elena Provenzano, Sarah E. Pinder, Anand D. Purushotham, Michael Pepper, and Vincent P. Wallace, "Terahertz pulsed spectroscopy of freshly excised human breast cancer," Opt. Express 17, 12444-12454 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-15-12444


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. P. Y. Han, G. C. Cho, and X. C. Zhang, "Time-domain transillumination of biological tissues with terahertz pulses," Opt. Lett. 25(4), 242-244 (2000). [CrossRef]
  2. P. Haring Bolívar, M. Nagel, F. Richter, M. Brucherseifer, H. Kurz, A. Bosserhoff, and R. Büttner, "Label-free THz sensing of genetic sequences: towards THz biochips," Philosophical Transactions of the Royal Society of London Series A-Mathematical Phys. Eng. Sci. 362(1815), 323-335 (2004). [CrossRef] [PubMed]
  3. A. G. Markelz, “Terahertz dielectric sensitivity to biomolecular structure and function,” IEEE J. Sel. Top. Quantum Electron. 14(1), 180-190 (2008). [CrossRef]
  4. B. M. Fischer, M. Walther, and P. U. Jepsen, ";Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy," Phys. Med. Biol. 47(21), 3807-3814 (2002). [CrossRef] [PubMed]
  5. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72-78 (2003). [CrossRef] [PubMed]
  6. A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, and D. D. Arnone, "Terahertz pulsed imaging of human breast tumors," Radiology 239(2), 533-540 (2006). [CrossRef] [PubMed]
  7. E. Pickwell, A. J. Fitzgerald, B. E. Cole, P. F. Taday, R. J. Pye, T. Ha, M. Pepper, and V. P. Wallace, “Simulating the response of terahertz radiation to basal cell carcinoma using ex vivo spectroscopy measurements,” J. Biomed. Opt. 10(6), 064021-064027 (2005). [CrossRef]
  8. M. Nagel, M. Forst, and H. Kurz, “THz biosensing devices: fundamentals and technology,” J. Phys. Condens. Matter 18(18), S601-S618 (2006). [CrossRef]
  9. J. R. Knab, J. Y. Chen, Y. F. He, and A. G. Markelz, "Terahertz measurements of protein relaxational dynamics," Proc. IEEE 95(8), 1605-1610 (2007). [CrossRef]
  10. E. Berry, G. C. Walker, A. J. Fitzgerald, N. N. Zinov'ev, M. Chamberlain, S. W. Smye, R. E. Miles, and M. A. Smith, "Do in vivo terahertz imaging systems comply with safety guidelines?," J. Laser Appl. 15(3), 192-198 (2003). [CrossRef]
  11. C. Rønne and S. R. Keiding, “Low frequency spectroscopy of liquid water using THz-time domain spectroscopy,” Journal of Molecular Liquids 101, 00093-00094 (2002). [CrossRef]
  12. V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, "Terahertz pulsed spectroscopy of human Basal cell carcinoma," Appl. Spectrosc. 60(10), 1127-1133 (2006). [CrossRef] [PubMed]
  13. A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59, 1–25 (2009). [CrossRef]
  14. J. R. Harris, M. E. Lippman, M. Morrow, and K. Osbourne, Diseases of the Breast (Lippincott, Williams & Wilkins, Philadelphia, 2004), pp. 719–744.
  15. H. Madjar, H. A. Ladner, W. Sauerbrei, A. Oberstein, H. Prömpeler, and A. Pfleiderer, “Preoperative staging of breast cancer by palpation, mammography and high-resolution ultrasound,” Ultrasound Obstet. Gynecol. 3(3), 185–190 (1993). [CrossRef] [PubMed]
  16. P. Taday and D. A. Newnham, “Advances in terahertz pulsed systems brings far-infrared spectroscopy into the spotlight,” Spectroscopy Europe 16, 20–24 (2004).
  17. R. M. Woodward, B. E. Cole, V. P. Wallace, R. J. Pye, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue,” Phys. Med. Biol. 47(21), 3853–3863 (2002). [CrossRef] [PubMed]
  18. E. Berry, J. W. Handley, A. J. Fitzgerald, W. J. Merchant, R. D. Boyle, N. N. Zinov’ev, R. E. Miles, J. M. Chamberlain, and M. A. Smith, “Multispectral classification techniques for terahertz pulsed imaging: an example in histopathology,” Med. Eng. Phys. 26(5), 423–430 (2004). [CrossRef] [PubMed]
  19. S. Nakajima, H. Hoshina, M. Yamashita, C. Otani, and N. Miyoshi, “Terahertz imaging diagnostics of cancer tissues with a chemometrics technique,” Appl. Phys. Lett. 90(4), 041102 (2007). [CrossRef]
  20. C. Reid, A. P. Gibson, J. C. Hebden, and V. P. Wallace, “The use of tissue mimicking phantoms in analysing contrast in THz pulsed imaging of biological tissue,” in Conference Digest of the Joint 32nd International Conference on Infrared and Millimetre Waves, and 15th International Conference on Terahertz Electronics, P. C. H. M. J. Griffin, T. J. Parker, K. P. Wood, ed. (IEEE, Cardiff, UK, 2007), pp. 567–568.
  21. P. Ashworth, P. O’Kelly, A. Purushotham, S. Pinder, M. Kontos, M. Pepper, and V. Wallace, "An Intra-operative THz Probe For Use During The Surgical Removal of Breast Tumors," in 33rd International Conference on Infrared, Millimeter, and Terahertz Waves, M. P. Siegel, ed., (IEEE, Pasadena, California, 2008).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited