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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 9 — Sep. 4, 2009

Mid-infrared absorption spectroscopy and differential damage in vitro between lipids and proteins by an all-fiber-integrated supercontinuum laser

Kevin Ke, Chenan Xia, Mohammed N. Islam, Michael J. Welsh, and Michael J. Freeman  »View Author Affiliations


Optics Express, Vol. 17, Issue 15, pp. 12627-12640 (2009)
http://dx.doi.org/10.1364/OE.17.012627


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Abstract

We identify and differentially damage lipids and proteins using wavelengths between 2.6 and 3.8 μm from a fiber-based supercontinuum (SC) laser. Absorption spectroscopy of the constituents of normal artery and atherosclerotic plaque, including adipose tissue, macrophages and foam cells, are measured by a SC laser in the mid-infrared. By using the laser light within the C-H fatty acid and cholesterol esters absorption band, we also demonstrate differential damage of lipid-rich adipose tissue without damaging the protein-rich blood vessel wall. The experiments use a novel SC laser that is all-fiber-integrated with no moving parts, covers a continuous spectrum ranging from ~0.8 to beyond 4.2 µm, and outputs a time-averaged power scalable up to 10.5 W.

© 2009 OSA

OCIS Codes
(170.1020) Medical optics and biotechnology : Ablation of tissue
(300.6340) Spectroscopy : Spectroscopy, infrared
(320.6629) Ultrafast optics : Supercontinuum generation

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 6, 2009
Revised Manuscript: June 11, 2009
Manuscript Accepted: June 23, 2009
Published: July 20, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Kevin Ke, Chenan Xia, Mohammed N. Islam, Michael J. Welsh, and Michael J. Freeman, "Mid-infrared absorption spectroscopy and differential damage in vitro between lipids and proteins by an all-fiber-integrated supercontinuum laser," Opt. Express 17, 12627-12640 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-15-12627


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