OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 10 — Oct. 2, 2009

Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light

Soren D. Konecky, Amaan Mazhar, David Cuccia, Anthony J. Durkin, John C. Schotland, and Bruce J. Tromberg  »View Author Affiliations


Optics Express, Vol. 17, Issue 17, pp. 14780-14790 (2009)
http://dx.doi.org/10.1364/OE.17.014780


View Full Text Article

Enhanced HTML    Acrobat PDF (359 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.

© 2009 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 9, 2009
Revised Manuscript: August 3, 2009
Manuscript Accepted: August 4, 2009
Published: August 5, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Soren D. Konecky, Amaan Mazhar, David Cuccia, Anthony J. Durkin, John C. Schotland, and Bruce J. Tromberg, "Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light," Opt. Express 17, 14780-14790 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-17-14780


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005). [PubMed]
  2. B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008). [PubMed]
  3. J. C. Hebden, “Advances in optical imaging of the newborn infant brain,” Psychophysiology 40(4), 501–510 (2003). [PubMed]
  4. V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005). [PubMed]
  5. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005). [PubMed]
  6. A. Bassi, C. D’Andrea, G. Valentini, R. Cubeddu, and S. Arridge, “Temporal propagation of spatial information in turbid media,” Opt. Lett. 33(23), 2836–2838 (2008). [PubMed]
  7. A. Joshi, W. Bangerth, K. Hwang, J. C. Rasmussen, and E. M. Sevick-Muraca, “Fully adaptive FEM based fluorescence optical tomography from time-dependent measurements with area illumination and detection,” Med. Phys. 33(5), 1299–1310 (2006). [PubMed]
  8. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009). [PubMed]
  9. D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009). [PubMed]
  10. D. J. Cuccia, D. Abookasis, R. D. Frostig, and B. J. Tromberg, “Quantitative in vivo imaging of tissue absorption, scattering, and hemoglobin concentration in rat cortex using spatially-modulated structured light,” in In Vivo Optical Imaging of Brain Function, 2nd ed., R. D. Frostig, ed. (CRC, 2009).
  11. J. R. Weber, D. J. Cuccia, A. J. Durkin, and B. J. Tromberg, “Noncontact imaging of absorption and scattering in layered tissue using spatially modulated structured light,” J. Appl. Phys. in press.
  12. V. A. Markel and J. C. Schotland, “Symmetries, inversion formulas, and image reconstruction for optical tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 70(5), 056616 (2004). [PubMed]
  13. J. C. Schotland and V. A. Markel, “Inverse scattering with diffusing waves,” J. Opt. Soc. Am. A 18(11), 2767–2777 (2001).
  14. S. D. Konecky, G. Y. Panasyuk, K. Lee, V. Markel, A. G. Yodh, and J. C. Schotland, “Imaging complex structures with diffuse light,” Opt. Express 16(7), 5048–5060 (2008). [PubMed]
  15. Z. M. Wang, G. Y. Panasyuk, V. A. Markel, and J. C. Schotland, “Experimental demonstration of an analytic method for image reconstruction in optical diffusion tomography with large data sets,” Opt. Lett. 30(24), 3338–3340 (2005).
  16. V. Lukic, V. A. Markel, and J. C. Schotland, “Optical tomography with structured illumination,” Opt. Lett. 34(7), 983–985 (2009). [PubMed]
  17. G. Y. Panasyuk, V. A. Markel, and J. C. Schotland, “Superresolution and corrections to the diffusion approximation in optical tomography,” Appl. Phys. Lett. 87(10), 101111 (2005).
  18. V. A. Markel and J. C. Schotland, “Inverse problem in optical diffusion tomography. II. Role of boundary conditions,” J. Opt. Soc. Am. A 19(3), 558–566 (2002).
  19. V. A. Markel, V. Mital, and J. C. Schotland, “Inverse problem in optical diffusion tomography. III. Inversion formulas and singular-value decomposition,” J. Opt. Soc. Am. A 20(5), 890–902 (2003).
  20. A. C. Kak, and M. Slaney, Principles of Computerized Imaging (IEEE, 1988).
  21. http://www.bli.uci.edu/ntroi/phantoms.php , retrieved April 24th, 2009.
  22. F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39(34), 6498–6507 (2000).
  23. H. P. Tuan, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71(6), 2500–2513 (2000).
  24. B. W. Pogue, T. O. McBride, J. Prewitt, U. L. Osterberg, and K. D. Paulsen, “Spatially variant regularization improves diffuse optical tomography,” Appl. Opt. 38(13), 2950–2961 (1999).
  25. J. C. Schotland and V. A. Markel, “Fourier-Laplace structure of the inverse scattering problem for the radiative transport equation,” Inverse Problems and Imaging 1, 147–154 (2007).
  26. G. Y. Panasyuk, J. C. Schotland, and V. A. Markel, “Radiative Transport Equation in Rotated Reference Frames,” J. Phys. A 39(1), 115–137 (2006).
  27. V. A. Markel, “Modified spherical hamonics method for solving the radiative transport equation,” Waves Random Media 14(1), L13–L19 (2004).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited