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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 10 — Oct. 2, 2009

Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification

Paola Taroni, Antonio Pifferi, Elena Salvagnini, Lorenzo Spinelli, Alessandro Torricelli, and Rinaldo Cubeddu  »View Author Affiliations


Optics Express, Vol. 17, Issue 18, pp. 15932-15946 (2009)
http://dx.doi.org/10.1364/OE.17.015932


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Abstract

Our multi-wavelength time-resolved optical mammograph was upgraded to improve its overall performances and extend its spectral coverage up to 1060 nm, with the aim of increasing the measurement sensitivity to the content of collagen in breast tissue. Late-gated intensity and reduced scattering images are routinely displayed for diagnostic purposes. Maps of tissue constituents (lipid, water and collagen) and blood parameters (total hemoglobin content and blood oxygenation) are built to highlight spatial changes due to physiological and pathological reasons. The upgraded instrument was tested on tissue phantoms. Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects).

© 2009 OSA

OCIS Codes
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 22, 2009
Revised Manuscript: July 24, 2009
Manuscript Accepted: August 13, 2009
Published: August 24, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Paola Taroni, Antonio Pifferi, Elena Salvagnini, Lorenzo Spinelli, Alessandro Torricelli, and Rinaldo Cubeddu, "Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification," Opt. Express 17, 15932-15946 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-18-15932


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