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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 11 — Oct. 21, 2009

Three-dimensional Bioluminescence Tomography based on Bayesian Approach

Jinchao Feng, Kebin Jia, Chenghu Qin, Guorui Yan, Shouping Zhu, Xing Zhang, Junting Liu, and Jie Tian  »View Author Affiliations

Optics Express, Vol. 17, Issue 19, pp. 16834-16848 (2009)

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Bioluminescence tomography (BLT) poses a typical ill-posed inverse problem with a large number of unknowns and a relatively limited number of boundary measurements. It is indispensable to incorporate a priori information into the inverse problem formulation in order to obtain viable solutions. In the paper, Bayesian approach has been firstly suggested to incorporate multiple types of a priori information for BLT reconstruction. Meanwhile, a generalized adaptive Gaussian Markov random field (GAGMRF) prior model for unknown source density estimation is developed to further reduce the ill-posedness of BLT on the basis of finite element analysis. Then the distribution of bioluminescent source can be acquired by maximizing the log posterior probability with respect to a noise parameter and the unknown source density. Furthermore, the use of finite element method makes the algorithm appropriate for complex heterogeneous phantom. The algorithm was validated by numerical simulation of a 3-D micro-CT mouse atlas and physical phantom experiment. The reconstructed results suggest that we are able to achieve high computational efficiency and accurate localization of bioluminescent source.

© 2009 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues

ToC Category:
Image Processing

Original Manuscript: May 26, 2009
Revised Manuscript: August 23, 2009
Manuscript Accepted: September 1, 2009
Published: September 8, 2009

Virtual Issues
Vol. 4, Iss. 11 Virtual Journal for Biomedical Optics

Jinchao Feng, Kebin Jia, Chenghu Qin, Guorui Yan, Shouping Zhu, Xing Zhang, Junting Liu, and Jie Tian, "Three-dimensional Bioluminescence Tomography based on Bayesian approach," Opt. Express 17, 16834-16848 (2009)

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