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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 12 — Nov. 10, 2009

Nanoimprinted plastic substrates for enhanced surface plasmon resonance imaging detection

Lidija Malic, Bo Cui, Maryam Tabrizian, and Teodor Veres  »View Author Affiliations


Optics Express, Vol. 17, Issue 22, pp. 20386-20392 (2009)
http://dx.doi.org/10.1364/OE.17.020386


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Abstract

Periodic nanostructures fabricated by Nanoimprint Litography (NIL) in low-cost plastic substrates and coated with thin gold film were explored for enhanced surface plasmon resonance imaging (SPRi) detection. Rigorous coupled-wave analysis was used to model the SPRi response of these nanostructured surfaces. Two-dimensional nanogratings and nanogrooves were fabricated on Zeonor 1060RTM by NIL and followed by metal deposition. The detection of refractive index changes in the dielectric layer due to bulk medium change, DNA immobilization and DNA hybridization events were monitored using SPRi to assess the corresponding signal amplification. The results indicate target-dependent sensitivity enhancement which is maximized for the detection of biomolecular binding events. The 500 nm period nanogrooves provided a 4 times SPR signal amplification compared to the conventional uniform gold film on SF-11 glass for DNA hybridization detection. Our work demonstrates that the use of nanoimprinted plastic substrates provides a low-cost solution for the SPR-based detection with sensitivity that meets the requirements in practical diagnostic applications.

© 2009 OSA

OCIS Codes
(050.2770) Diffraction and gratings : Gratings
(120.1880) Instrumentation, measurement, and metrology : Detection
(130.6010) Integrated optics : Sensors
(240.6680) Optics at surfaces : Surface plasmons
(260.3910) Physical optics : Metal optics
(310.6860) Thin films : Thin films, optical properties

ToC Category:
Optics at Surfaces

History
Original Manuscript: August 17, 2009
Revised Manuscript: September 23, 2009
Manuscript Accepted: September 24, 2009
Published: October 23, 2009

Virtual Issues
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Lidija Malic, Bo Cui, Maryam Tabrizian, and Teodor Veres, "Nanoimprinted plastic substrates for enhanced surface plasmon resonance imaging detection," Opt. Express 17, 20386-20392 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-22-20386


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