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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 13 — Dec. 2, 2009

Phase and amplitude sensitivities in surface plasmon resonance bio and chemical sensing

Andrei V. Kabashin, Sergiy Patskovsky, and Alexander N. Grigorenko  »View Author Affiliations


Optics Express, Vol. 17, Issue 23, pp. 21191-21204 (2009)
http://dx.doi.org/10.1364/OE.17.021191


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Abstract

We consider amplitude and phase characteristics of light reflected under the Surface Plasmon Resonance (SPR) conditions and study their sensitivities to refractive index changes associated with biological and chemical sensing. Our analysis shows that phase can provide at least two orders of magnitude better detection limit due to the following reasons: (i) Maximal phase changes occur in the very dip of the SPR curve where the vector of probing electric field is maximal, whereas maximal amplitude changes are observed on the resonance slopes: this provides a one order of magnitude larger sensitivity of phase to refractive index variations; (ii) Under a proper design of a detection scheme, phase noises can be orders of magnitude lower compared to amplitude ones, which results in a much better signal-to-noise ratio; (iii) Phase offers much better possibilities for signal averaging and filtering, as well as for image treatment. Applying a phase-sensitive SPR polarimetry scheme and using gas calibration model, we experimentally demonstrate the detection limit of 10−8 RIU, which is about two orders of magnitude better compared to amplitude-sensitive schemes. Finally, we show how phase can be employed for filtering and treatment of images in order to improve signal-to-noise ratio even in relatively noisy detection schemes. Combining a much better physical sensitivity and a possibility of imaging and sensing in micro-arrays, phase-sensitive methodologies promise a substantial upgrade of currently available SPR technology.

© 2009 OSA

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Optics at Surfaces

History
Original Manuscript: September 25, 2009
Revised Manuscript: October 27, 2009
Manuscript Accepted: October 27, 2009
Published: November 6, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Andrei V. Kabashin, Sergiy Patskovsky, and Alexander N. Grigorenko, "Phase and amplitude sensitivities in surface plasmon resonance bio and chemical sensing," Opt. Express 17, 21191-21204 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-23-21191


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