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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 4 — Apr. 1, 2009

Numerical simulation of an optical chromatographic separator

Alex Terray, H. D. Ladouceur, Mark Hammond, and Sean J. Hart  »View Author Affiliations

Optics Express, Vol. 17, Issue 3, pp. 2024-2032 (2009)

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Optical chromatography achieves microscale optical manipulation through the balance of optical and hydrodynamic forces on micron sized particles entrained in microfluidic flow traveling counter to the propagation of a mildly focused laser beam. The optical pressure force on a particle is specific to each particle’s size, shape and refractive index. So far, these properties have been exploited in our lab to concentrate, purify and separate injected samples. But as this method advances into more complex optofluidic systems, a need to better predict behavior is necessary. Here, we present the development and experimental verification of a robust technique to simulate particle trajectories in our optical chromatographic device. We also show how this new tool can be used to gather better qualitative and quantitative understanding in a two component particle separation.

© 2009 Optical Society of America

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(170.1420) Medical optics and biotechnology : Biology

ToC Category:
Optical Trapping and Manipulation

Original Manuscript: September 29, 2008
Revised Manuscript: December 12, 2008
Manuscript Accepted: December 14, 2008
Published: January 30, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Alex Terray, H. D. Ladouceur, Mark Hammond, and Sean J. Hart, "Numerical simulation of an optical chromatographic separator," Opt. Express 17, 2024-2032 (2009)

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