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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Miniature swept source for point of care Optical Frequency Domain Imaging

Brian D. Goldberg, S.M. Reza Motaghian Nezam, Priyanka Jillella, Brett E. Bouma, and Guillermo J. Tearney  »View Author Affiliations

Optics Express, Vol. 17, Issue 5, pp. 3619-3629 (2009)

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Point of care (POC) medical technologies require portable, small, robust instrumentation for practical implementation. In their current embodiment, optical frequency domain imaging (OFDI) systems employ large form-factor wavelength-swept lasers, making them impractical in the POC environment. Here, we describe a first step toward a POC OFDI system by demonstrating a miniaturized swept-wavelength source. The laser is based on a tunable optical filter using a reflection grating and a miniature resonant scanning mirror. The laser achieves 75 nm of bandwidth centered at 1340 nm, a 0.24 nm instantaneous line width, a 15.3 kHz repetition rate with 12 mW peak output power, and a 30.4 kHz A-line rate when utilizing forward and backward sweeps. The entire laser system is approximately the size of a deck of cards and can operate on battery power for at least one hour.

© 2009 Optical Society of America

OCIS Codes
(140.3600) Lasers and laser optics : Lasers, tunable
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 20, 2008
Revised Manuscript: January 9, 2009
Manuscript Accepted: January 14, 2009
Published: February 24, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Brian D. Goldberg, S. M. R. Motaghian Nezam, Priyanka Jillella, Brett E. Bouma, and Guillermo J. Tearney, "Miniature swept source for point of care Optical Frequency Domain Imaging," Opt. Express 17, 3619-3629 (2009)

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  1. C. P. Price and L. J. Kricka, "Improving Healthcare Accessibility through Point-of-Care Technologies," Clin. Chem. 53, 1665-1675 (2007). [CrossRef] [PubMed]
  2. Y. Beaulieu, "Bedside echocardiography in the assessment of the critically ill," Crit. Care. Med. 35, S235-S249 (2007). [CrossRef] [PubMed]
  3. S. Gupta and D. Madoff, "Image-guided percutaneous needle biopsy in cancer diagnosis and staging," Tech. Vasc. Interv. Radiol. 10, 88-101 (2007). [CrossRef] [PubMed]
  4. B. D. Goldberg, N. V. Iftimia, J. E. Bressner, M. B. Pitman, E. Halpern, B. E. Bouma, and G. J. Tearney, "An automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration breast biopsy.," J. Biomed. Opt. 13, 014014 (2008). [CrossRef] [PubMed]
  5. Q1. A. M. Zysk and S. A. Boppart, "Computational methods for analysis of human breast tumor tissue in optical coherence tomography images," J. Biomed. Opt. 11(2006). [CrossRef] [PubMed]
  6. P.-L. Hsiung, L. Pantanowitz, A. D. Aguirre, Y. Chen, D. Phatak, T. H. Ko, S. Bourquin, S. J. Schnitt, S. Raza, J. L. Connolly, H. Mashimo, and J. G. Fujimoto, "Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines," Gastrointestinal Endoscopy 62, 561-574 (2005). [CrossRef] [PubMed]
  7. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I.-K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, "Comprehensive volumetric optical microscopy in vivo," Nat. Med. 12, 1429-1433 (2007). [CrossRef]
  8. V. Westphal, A. M. Rollins, J. Willis, M. V. SivakJr, and J. A. Izatt, "Correlation of endoscopic optical coherence tomography with histology in the lower-GI tract," Gastrointestinal Endoscopy 61, 537-546 (2005). [CrossRef] [PubMed]
  9. M. A. S. Frable and W. J. Frable, "Fine-Needle Aspiration Biopsy of Salivary-Glands," Laryngoscope 101, 245-249 (1991). [CrossRef] [PubMed]
  10. S. R. S. Mandreker, N. S. Nadkarni, R. G. W. Pinto, and S. Menezes, "Role of Fine-Needle Aspiration Cytology as the Initial Modality in the Investigation of Thyroid Lesions," Acta. Cytologica 39, 898-904 (1995). [PubMed]
  11. S. Klein, "Evaluation of Palpable Breast Masses," American Family Physician 71, 1731-1738 (2005). [PubMed]
  12. Q2. N. S. Scott Boerner, "Specimen adequacy and false-negative diagnosis rate in fine-needle aspirates of palpable breast masses," Cancer Cytopathology 84, 344-348 (1998). [CrossRef]
  13. W. H. Hindle and E. C. Chen, "Accuracy of mammographic appearances after breast fine-needle aspiration," American Journal of Obstetrics and Gynecology 176, 1286-1290 (1997). [CrossRef] [PubMed]
  14. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, "Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity," Opt. Lett. 25, 114-116 (2000). [CrossRef]
  15. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003). [CrossRef] [PubMed]
  16. Q3. A. M. Zysk, S. G. Adie, J. J. Armstrong, M. S. Leight, A. Paduch, D. D. Sampson, F. T. Nguyne, and S. A. Boppart, "Needle-based refractive index measurement using low-coherence interferometry," Opt. Lett. 32(2007). [CrossRef] [PubMed]
  17. X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, "Imaging needle for optical coherence tomography," Opt. Lett. 25, 1520-1522 (2000). [CrossRef]
  18. M. Johns, C. A. Giller, D. German, and H. Liu, "Determination of reduced scattering coefficient of biological tissue from a needle-like probe., " Opt. Express 13, 4828-4842 (2005). [CrossRef] [PubMed]
  19. Y. Z. Zhu and A. B. Wang, "Miniature fiber-optic pressure sensor," IEEE Photon. Technol. Lett. 17, 447-449 (2005). [CrossRef]
  20. W. A. Reed, M. F. Yan, and M. J. Schnitzer, "Gradient-index fiber-optics microprobes for minimally invasive in vivo low-coherence interferometry," Opt. Lett. 27, 1794-1796 (2002). [CrossRef]
  21. M. Choma, M. Sarunic, C. Yang, and J. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003). [CrossRef] [PubMed]
  22. R. Huber, M. Wojtkowski, and J. G. Fujimoto, "Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography " Opt. Express 14, 3225-3237 (2006). [CrossRef] [PubMed]
  23. Q4. J. F. de Boer, S. M. Srinivas, B. H. Park, T. H. Pham, Z. P. Chen, T. E. Milner, and J. S. Nelson, "Polarization effects in optical coherence tomography of various biological tissues," IEEE J. Sel. Top. Quantum Electron. 5, 1200-1204 (1999). [CrossRef]
  24. W. Y. Oh, S. H. Yun, B. J. Vakoc, M. Shishkov, A. E. Desjardins, B. H. Park, J. F. de Boer, G. J. Tearney, and B. E. Bouma, "High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing " Opt. Express 16, 1096-1103 (2008). [CrossRef] [PubMed]
  25. B. Vakoc, S. Yun, J. de Boer, G. Tearney, and B. Bouma, "Phase-resolved optical frequency domain imaging," Opt. Express 13, 5483-5493 (2005). [CrossRef] [PubMed]
  26. S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Opt. Lett. 28, 1981-1983 (2003). [CrossRef] [PubMed]
  27. S. H. Yun, C. Boudoux, M. C. Pierce, J. F. d. Boer, G. J. Tearney, and B. E. Bouma, "Extended-cavity semiconductor wavelength-swept laser for biomedical imaging," IEEE Photon. Technol. Lett. 16, 293-295 (2004). [CrossRef]
  28. M. Choma, K. Hsu, and J. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 044009 (2005). [CrossRef]
  29. A. R. Tumlinson, J. K. Barton, B. Povazay, H. Sattman, A. Unterhuber, R. A. Leitgeb, and W. Drexler, "Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon," Opt. Express 14, 1879-1887 (2006). [CrossRef]
  30. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342 (1997). [CrossRef] [PubMed]
  31. Q5. C. Changho, A. Morosawa, and T. Sakai, "High-Speed Wavelength-Swept Laser Source With High-Linearity Sweep for Optical Coherence Tomography," IEEE J. Sel. Top. Quantum Electron. 14, 235-242 (2008). [CrossRef]
  32. S. W. Lee, C. S. Kim, and B. M. Kim, "External Line-Cavity Wavelength-Swept Source at 850 nm for Optical Coherence Tomography," IEEE Photon. Technol. Lett. 19, 176-178 (2007). [CrossRef]
  33. R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable, "Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm," Opt. Express 13, 10523-10538 (2005). [CrossRef] [PubMed]
  34. R. Huber, M. Wojtkowski, K. Taira, J. Fujimoto, and K. Hsu, "Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles," Opt. Express 13, 3513-3528 (2005). [CrossRef] [PubMed]
  35. W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103903 (2006). [CrossRef]
  36. S. M. R. Motaghian Nezam, "High-speed polygon-scanner-based wavelength-swept laser source in the telescope-less configurations with application in optical coherence tomography," Opt. Lett. 33, 1741-1743 (2008). [CrossRef] [PubMed]
  37. W. Y. Oh, S. H. Yun, G. J. Tearney, and B. E. Bouma, "115 kHz tuning repitition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005). [CrossRef] [PubMed]
  38. M. B. Pitman, (personal communication, 2007).

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