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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration

Yueli Chen, Laurel N. Vuong, Jonathan Liu, Joseph Ho, Vivek J. Srinivasan, Iwona Gorczynska, Andre J. Witkin, Jay S. Duker, Joel Schuman, and James G. Fujimoto  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 4046-4060 (2009)
http://dx.doi.org/10.1364/OE.17.004046


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Abstract

Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral/Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral/Fourier domain OCT instrument with 3.5 µm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric datasets of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.

© 2009 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
OCT in Retinal Disease

History
Original Manuscript: December 10, 2008
Revised Manuscript: February 12, 2009
Manuscript Accepted: February 21, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express

Citation
Yueli Chen, Laurel N. Vuong, Jonathan Liu, Joseph Ho, Vivek J. Srinivasan, Iwona Gorczynska, Andre J. Witkin, Jay S. Duker, Joel Schuman, and James G. Fujimoto, "Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration," Opt. Express 17, 4046-4060 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-5-4046


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