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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography

Yimin Wang, Amani Fawzi, Ou Tan, John Gil-Flamer, and David Huang  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 4061-4073 (2009)
http://dx.doi.org/10.1364/OE.17.004061


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Abstract

We present human retinal blood flow investigation for diabetic patients using Doppler Fourier domain optical coherence tomography (FD-OCT). The scanning pattern consisted of two concentric circles around the optic nerve head. The blood flow in one patient with diabetes and no retinpathy and another patient with treated proliferative diabetic retinopathy were measured. The patient without retinopathy showed a total blood flow value at the lower level of the normal range. The flow distribution between superior and inferior retina was balanced. The patient with diabetic retinopathy had a flow value lower than the normal people. Our study shows that Doppler FD-OCT can be used to evaluate the total retinal blood flow in patients with retinal diseases.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
OCT in Retinal Disease

History
Original Manuscript: September 10, 2008
Revised Manuscript: January 19, 2009
Manuscript Accepted: February 13, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express

Citation
Yimin Wang, Amani Fawzi, Ou Tan, John Gil-Flamer, and David Huang, "Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography," Opt. Express 17, 4061-4073 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-5-4061


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References

  1. C. J. Pournaras, E. Rungger-Brändle, C. E. Riva, S. H. Hardarson, and E. Stefansson, "Regulation of retinal blood flow in health and disease," Prog. Retin. Eye Res. 27, 284-330 (2008). [CrossRef] [PubMed]
  2. A. Mendivil, V. Cuartero, and M. P. Mendivil, "Ocular blood flow velocities in patients with proliferative diabetic retinopathy and healthy volunteers: a prospective study," Br. J. Ophthalmol. l 79, 413-416 (1995). [CrossRef]
  3. D. Guven, H. Ozdemir, and B. Hasanreisoglu, "Hemodynamic alterations in diabetic retinopathy," Ophthalmology 103, 1245-1249 (1996). [PubMed]
  4. J. R. MacKinnon, G. McKillop, C. O'Brien, K. Swa, Z. Butt, and P. Nelson, "Colour Doppler imaging of the ocular circulation in diabetic retinopathy," Acta Ophthalmol. Scand. 78, 386-389 (2000). [CrossRef] [PubMed]
  5. S. Fujioka, K. Karashima, N. Nishikawa, and Y. Saito, "Correlation between higher blood flow velocity in the central retinal vein than in the central retinal artery and severity of nonproliferative diabetic retinopathy," Jpn. J. Ophthalmol. 50, 312-317 (2006). [CrossRef] [PubMed]
  6. M. Lorenzi, G. T. Feke, E. Cagliero, L. Pitler, D. A. Schaumberg, F. Berisha, D. M. Nathan, and J. W. McMeel, "Retinal haemodynamics in individuals with well-controlled type 1 diabetes," Diabetologia 51, 361-364 (2008). [CrossRef]
  7. D. Huang, D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  8. M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102, 748-756 (1995). [PubMed]
  9. C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102, 217-229 (1995). [PubMed]
  10. M. R. Hee, C. R. Baumal, C. A. Puliafito, J. S. Duker, E. Reichel, J. R. Wilkins, J. G. Coker, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103, 1260-1270 (1996). [PubMed]
  11. J. S. Shuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113, 586-596 (1995).
  12. J. S. Shuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujomoto, and E. A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Curr. Opin. Ophthalmol. 6, 89-95 (1995). [CrossRef]
  13. X. J. Wang, T. E. Milner, and J. S. Nelson, "Characterization of fluid flow velocity by optical Doppler tomography," Opt. Lett. 20, 1337-1339 (1995). [CrossRef] [PubMed]
  14. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch. "In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography," Opt. Lett. 22, 1439-1441 (1997). [CrossRef]
  15. Y. Zhao, Z. Chen, C. Saxer, Q. Shen, S. Xiang, J. F. de Boer, and J. S. Nelson. "Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow," Opt. Lett. 25, 1358-1360 (2000). [CrossRef]
  16. S. Yazdanfar, A. M. Rollins, and J. A. Izatt, "In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography," Arch. Ophthalmol. 121, 235-239 (2003). [PubMed]
  17. V. X. D. Yang, M. Gordon, E. S. Yue, S. Lo, B. Qi, J. Pekar, A. Mok, B. Wilson, and I. Vitkin, "High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamic of Xenopus Laevis," Opt. Express. 11, 1650-1658 (2003). [CrossRef] [PubMed]
  18. S. Yazdanfar, A. M. Rollins, and J. A. Izatt. "Imaging and velocity of the human retinal circulation with color Doppler optical coherence tomography," Opt. Lett. 25, 1448-1450 (2000). [CrossRef]
  19. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. Park, G. Tearney, B. Bouma, T. Chen, and J. de Boer, "In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography," Opt. Express. 11, 3490-3497 (2003). [CrossRef] [PubMed]
  20. R. A. Leitgeb, L. Schmetterer, C. K. Hitzenberger, A. F. Fercher, F. Berisha, M. Wojtkowski, and T. Bajraszewski, "Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography," Opt. Lett. 29, 171-173 (2004). [CrossRef] [PubMed]
  21. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, "In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography," J. Biomed. Opt. 12, 041215 (2007). [CrossRef] [PubMed]
  22. S. Makita, T. Fabritius, and Y. Yasuno, "Quantitative retinal-blood flow measurement with three dimensional vessel geometry determination using ultrahigh-resolution Doppler optical coherence angiography," Opt. Lett. 33, 836-838 (2008). [CrossRef] [PubMed]
  23. R. Michaely, A. H. Bachmann, M. L. Villiger, C. Blatter, T. Lasser and R. A. Leitgeb, "Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography," J. Biomed Opt. 12, 041213 (2007). [CrossRef] [PubMed]
  24. H. M. Wehbe, M. Ruggeri, S. Jiao, G. Gregori, C. A. Puliafito, and W. Zhao, "Calibration of blood flow measurement with spectral domain optical coherence tomography," in Biomedical Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper BMD75.
  25. H. Wehbe, M. Ruggeri, S. Jiao, G. Gregori, C. A. Puliafito, and W. Zhao, "Automatic retinal blood flow calculation using spectral domain optical coherence tomography," Opt. Express 15, 15193-15206 (2007). [CrossRef] [PubMed]
  26. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, "Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence," J. Biomed. Opt. 13, 064003 (2008). [CrossRef]
  27. B. A. Bower, M. Zhao, R. J. Zawadzki, and J. A. Izatt, "Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation," J. Biomed. Opt. 12, 041214 (2007). [CrossRef] [PubMed]
  28. Y. Wang, A. Lu, J. Gil-Flamer, O. Tan, D. Huang, "Measurement of total blood flow in the normal human retina using Doppler Fourier domain optical coherence tomography," Br. J. Ophthalmol. (in press). [PubMed]
  29. C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, "Blood velocity and volumetric flow rate in human retinal vessels," Invest. Ophthalmol. Vis. Sci. 26, 1124-1132 (1985). [PubMed]
  30. Q1. Jr. P. S. Garcia, P. T. Garcia, and R. B. Rosen, "Retinal blood flow in the normal human eye using the canon laser blood flowmeter," Ophthalmic Res. 34, 295-299 (2002). [CrossRef]
  31. C. W. C. Klaver, C. W. R. Wolfs, R. J. Vingerling, and T. V. P. de Jong, "Age-specific prevalence and causes of blindness and visual impairment in an older population," Arch. Ophthalmol. 116, 653-658 (2007).
  32. K. S. West, R. Klein, J. Rodriguez, B. Munoz, T. A. Broman, R. Sanchez, and R. Snyder, "Diabetes and diabetic retinopathy in a Mexican-American population," Diabetes Care 24, 1204-1209 (2001). [CrossRef] [PubMed]
  33. J. Flammer, S. Orgul, V. P. Costa, N. Orzalesi, G. K. Krieqlstein, L. M. Serra, J. P. Renard, and E. Stefansson, "The impact of ocular blood flow in glaucoma," Prog Retin. Eye Res. 21, 359-393 (2002). [CrossRef] [PubMed]
  34. J. Flammer, "The vascular concept of glaucoma," Surv. Ophthalmol. 38, S3-S6 (1994). [CrossRef] [PubMed]
  35. J. Kerr, P. Nelson, and C. O’Brien. "A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension," Am. J. Ophthalmol. 126, 42-51 (1998). [CrossRef] [PubMed]

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