OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina

Erich Götzinger, Michael Pircher, Bernhard Baumann, Christian Ahlers, Wolfgang Geitzenauer, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 4151-4165 (2009)
http://dx.doi.org/10.1364/OE.17.004151


View Full Text Article

Enhanced HTML    Acrobat PDF (977 KB) Open Access ISP Components
Browse Datasets: MIDAS Click for help

Full-Text PDF contains links to datasets. See ISP homepage for software requirements and other information.





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Polarization sensitive OCT has recently been shown to provide tissue specific contrast, enabling direct identification of retinal layers based on the intrinsic properties of their interaction with light. However, the capabilities of displaying and analyzing 3D datasets in scientific publications were rather limited. Within the framework of the Interactive Science Publishing project, we present new ways of displaying and analyzing 3D sets of various polarization parameters recorded in healthy and diseased human retinas. These datasets can be interactively explored by the reader. Furthermore, we provide data of the 3D distribution of backscattered Stokes vectors to allow the reader to develop and test their own data processing algorithms.

© 2009 Optical Society of America

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(230.5440) Optical devices : Polarization-selective devices

ToC Category:
Functional OCT

History
Original Manuscript: October 30, 2008
Revised Manuscript: January 15, 2009
Manuscript Accepted: January 22, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express

Citation
Erich Götzinger, Michael Pircher, Bernhard Baumann, Christian Ahlers, Wolfgang Geitzenauer, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger, "Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina," Opt. Express 17, 4151-4165 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-5-4151


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. B. Bouma, and G. Tearney, Handbook of optical coherence tomography (Marcel Dekker, New York, 2002).
  3. A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography - principles and applications," Rep. Prog. Phys. 66, 239-303 (2003). [CrossRef]
  4. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
  5. G. Häusler, and M. W. Lindner, ""Coherence radar" and "spectral radar" - New tools for dermatological diagnosis," J Biomed Opt 3, 21-31 (1998). [CrossRef]
  6. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
  7. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889. [CrossRef] [PubMed]
  8. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003). [CrossRef] [PubMed]
  9. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-18-2183. [CrossRef] [PubMed]
  10. T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005). [CrossRef] [PubMed]
  11. U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46, 3393-3402 (2005). [CrossRef] [PubMed]
  12. M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005). [CrossRef] [PubMed]
  13. M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, "Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging," J. Opt. Soc. Am. B-Opt.Phys. 9, 903-908 (1992). [CrossRef]
  14. J. F. deBoer, T. E. Milner, M. J. C. vanGemert, and J. S. Nelson, "Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography," Opt. Lett. 22, 934-936 (1997). [CrossRef]
  15. J. F. de Boer, T. E. Milner, and J. S. Nelson, "Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography," Opt. Lett. 24, 300-302 (1999). [CrossRef]
  16. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001). [CrossRef] [PubMed]
  17. G. Yao, and L. V. Wang, "Two-dimensional depth-resolved Mueller matrix characterization of biological tissue by optical coherence tomography," Opt. Lett. 24, 537-539 (1999). [CrossRef]
  18. S. L. Jiao, and L. H. V. Wang, "Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography," J. Biomed. Opt. 7, 350-358 (2002). [CrossRef] [PubMed]
  19. C. K. Hitzenberger, E. Götzinger, M. Sticker, M. Pircher, and A. F. Fercher, "Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography," Opt. Express 9, 780-790 (2001). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-9-13-780. [CrossRef] [PubMed]
  20. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004). [CrossRef] [PubMed]
  21. M. Todorovic, S. L. Jiao, and L. V. Wang, "Determination of local polarization properties of biological samples in the presence of diattenuation by use of Mueller optical coherence tomography," Opt. Lett. 29, 2402-2404 (2004). [CrossRef] [PubMed]
  22. N. J. Kemp, H. N. Zaatari, J. Park, H. G. Rylander, and T. E. Milner, "Form-biattenuance in fibrous tissues measured with polarization-sensitive optical coherence tomography (PS-OCT)," Opt. Express 13, 4611-4628 (2005). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-12-4611. [CrossRef] [PubMed]
  23. E. Götzinger, M. Pircher, and C. K. Hitzenberger, "High speed spectral domain polarization sensitive optical coherence tomography of the human retina," Opt. Express 13, 10217-10229 (2005). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-25-10217. [CrossRef] [PubMed]
  24. B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002). [CrossRef]
  25. B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004). [CrossRef] [PubMed]
  26. M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, "Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT," Opt. Express 12, 5940-5951 (2004). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-24-5940. [CrossRef] [PubMed]
  27. M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Human macula investigated in vivo with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 47, 5487-5494 (2006). [CrossRef] [PubMed]
  28. S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008). [CrossRef] [PubMed]
  29. M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, "Imaging polarimetry in age-related macular degeneration," Invest. Ophthalmol. Vis. Sci. 49, 2661-2667 (2008). [CrossRef] [PubMed]
  30. M. Mujat, B. H. Park, B. Cense, T. C. Chen, and J. F. de Boer, "Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination," J. Biomed. Opt. 12, 6 (2007). [CrossRef] [PubMed]
  31. M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, "Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry," J. Biomed. Opt. 13, 10 (2008). [CrossRef] [PubMed]
  32. E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, "Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: A comparison," Journal of Biophotonics 1, 129-139 (2008). [CrossRef]
  33. M. Pircher, E. Götzinger, B. Baumann, and C. K. Hitzenberger, "Corneal birefringence compensation for polarization sensitive optical coherence tomography of the human retina," J. Biomed. Opt. 12, 10 (2007). [CrossRef] [PubMed]
  34. E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurt, and C. K. Hitzenberger, "Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography," Optics Express 16, 16416-16428 (2008). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-16-21-16416. [CrossRef]
  35. S. L. Jiao, G. Yao, and L. H. V. Wang, "Depth-resolved two-dimensional Stokes vectors of backscattered light and Mueller matrices of biological tissue measured with optical coherence tomography," Appl. Optics 39, 6318-6324 (2000). [CrossRef]
  36. S. G. Adie, T. R. Hillman, and D. D. Sampson, "Detection of multiple scattering in optical coherence tomography using the spatial distribution of Stokes vectors," Optics Express 15, 18033-18049 (2007). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-15-26-18033. [CrossRef] [PubMed]
  37. S. W. Lee, J. Y. Yoo, J. H. Kang, M. S. Kang, S. H. Jung, Y. Chong, D. S. Cha, K. H. Han, and B. M. Kim, "Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography," Opt. Express 16, 2709-2719 (2008). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-16-4-2709. [CrossRef] [PubMed]
  38. P. Thevenaz, U. E. Ruttimann, and M. Unser, "A pyramid approach to subpixel registration based on intensity," Ieee Transactions on Image Processing 7, 27-41 (1998). [CrossRef]
  39. M. Pircher, E. Goetzinger, R. Leitgeb, and C. K. Hitzenberger, "Three dimensional polarization sensitive OCT of human skin in vivo," Opt. Express 12, 3236-3244 (2004). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-14-3236. [CrossRef] [PubMed]
  40. H. Bagga, D. S. Greenfield, and W. J. Feuer, "Quantitative assessment of atypical birefringence images using scanning laser polarimetry with variable corneal compensation," Am. J. Ophthalmol. 139, 437-446 (2005). [CrossRef] [PubMed]
  41. E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, "Analysis of the origin of atypical scanning laser polarimetry patterns by polarization sensitive optical coherence tomography," Invest Ophthalmol Vis Sci 49, 5366-5372 (2008). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Supplementary Material


» Media 1: AVI (4134 KB)     
» Media 2: AVI (7699 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited