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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography

Yuankai K. Tao, Kristen M. Kennedy, and Joseph A. Izatt  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 4177-4188 (2009)
http://dx.doi.org/10.1364/OE.17.004177


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Abstract

We demonstrate in vivo velocity-resolved, volumetric bidirectional blood flow imaging in human retina using single-pass flow imaging spectral domain optical coherence tomography (SPFI-SDOCT). This technique uses previously described methods for separating moving and non-moving scatterers within a depth by using a modified Hilbert transform. Additionally, a moving spatial frequency window is applied, creating a stack of depth-resolved images of moving scatterers, each representing a finite velocity range. The resulting velocity reconstruction is validated with and strongly correlated to velocities measured with conventional Doppler OCT in flow phantoms. In vivo velocity-resolved flow mapping is acquired in healthy human retina and demonstrate the measurement of vessel size, peak velocity, and total foveal blood flow with OCT.

© 2009 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Functional OCT

History
Original Manuscript: October 30, 2008
Revised Manuscript: February 10, 2009
Manuscript Accepted: February 26, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express

Citation
Yuankai K. Tao, Kristen M. Kennedy, and Joseph A. Izatt, "Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography," Opt. Express 17, 4177-4188 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-5-4177


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