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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Whispering gallery mode carousel – a photonic mechanism for enhanced nanoparticle detection in biosensing

S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky, and F. Vollmer  »View Author Affiliations


Optics Express, Vol. 17, Issue 8, pp. 6230-6238 (2009)
http://dx.doi.org/10.1364/OE.17.006230


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Abstract

Individual nanoparticles in aqueous solution are observed to be attracted to and orbit within the evanescent sensing ring of a Whispering Gallery Mode micro-sensor with only microwatts of driving power. This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors. Resonance frequency fluctuations, caused by the radial Brownian motion of the nanoparticle, reveal the radial trapping potential and the nanoparticle size. Since the attractive forces draw particles to the highest evanescent intensity at the surface, binding steps are found to be uniform.

© 2009 Optical Society of America

OCIS Codes
(020.7010) Atomic and molecular physics : Laser trapping
(040.1880) Detectors : Detection
(230.3990) Optical devices : Micro-optical devices

ToC Category:
Optical Trapping and Manipulation

History
Original Manuscript: February 25, 2009
Revised Manuscript: March 31, 2009
Manuscript Accepted: March 31, 2009
Published: April 1, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky, and F. Vollmer, "Whispering gallery mode carousel – a photonic mechanism for enhanced nanoparticle detection in biosensing," Opt. Express 17, 6230-6238 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-8-6230


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References

  1. A. Ashkin and J. M. Dziedzic, "Optical Trapping and Manipulation of Viruses and Bacteria," Science 235,1517-1520 (1987). [CrossRef] [PubMed]
  2. F. Vollmer and S. Arnold, "Whispering-gallery-mode biosensing: label-free detection down to single molecules," Nature Methods 5, 591-596 (2008). [CrossRef] [PubMed]
  3. A. M. Armani, R. P. Kulkarni, S. E. Fraser, R. C. Flagan, and K. J. Vahala, "Label-free, single-molecule detection with optical microcavities," Science 317, 783-787 (2007). [CrossRef] [PubMed]
  4. T. M. Squires, R. J. Messinger, and S. R. Manalis, "Making it stick: convection, reaction and diffusion in surface-based biosensors," Nature Biotechnol. 26, 417-426 (2008). [CrossRef]
  5. J. C. Knight, G. Chung, F. Jacques, and T. A. Birks, "Phase-matched excitation of whispering-gallery-mode resonances by a fiber taper," Opt. Lett. 22, 1129-1131(1997). [CrossRef] [PubMed]
  6. L. Yang, T. Carmon, B. Min, S. M. Spillane, and K. J. Vahala, "Erbium-doped and Raman microlasers on a silicon chip fabricated by the sol-gel process," Appl. Phys. Lett. 86, 091114 (2005). [CrossRef]
  7. S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer, "Shift of whispering-gallery modes in microspheres by protein adsorption," Opt. Lett. 28,272-274 (2003). [CrossRef] [PubMed]
  8. L ? (?/4?)(ns2-nm2)-1/2, D = 2nm2 (2ns)1/2(nnp2 - nm2)/(ns2 - nm2)(nnp2 + 2nm2), where ns, nm, and nnp are the refractive indices of the microsphere (1.45), aqueous medium (1.33), and nanoparticle (1.5 for virus and 1.59 for polystyrene; D = 1.50 and 2.26 respectively).
  9. A. Ashkin, J. M. Dziedzic, J. E. Bjorkholm, and S. Chu, "Observation of a Single-Beam Gradient Force Optical Trap for Dielectric Particles," Opt. Lett. 11,288-290 (1986). [CrossRef] [PubMed]
  10. Y. Roichman, B. Sun, Y. Roichman, J. Amato-Grill, and D. G. Grier, "Optical forces arising from phase gradients," Phys. Rev. Lett. 100,013602 (2008). [CrossRef] [PubMed]
  11. J. N. Izraelachvili, Intermolecular And Surfaces Forces. 173-191 (Academic Press, Inc., San Diego, CA, 1987).
  12. I. Teraoka and S. Arnold, "Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications," J. Opt. Soc. Am. B 23,1381-1389 (2006). [CrossRef]
  13. F. Vollmer, S. Arnold, and D. Keng, "Single Virus Detection from the Reactive Shift of a Whispering-Gallery Mode," Proc. Natl. Acad. Sci. USA 105,20701-20704 (2008). [CrossRef] [PubMed]
  14. The translation from a size to a mass spectrum requires knowledge of mass density.
  15. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, "Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides," Nature 457,71-75 (2009) [CrossRef] [PubMed]

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